How Does Otigo Work: Mechanism of Action & Metabolic Effects
Key Takeaways
- How it works: Phenazone (anti-inflammatory) + Lidocaine (numbing agent) provide dual-action pain relief
- Who can use: Adults & children with intact eardrums for middle ear pain
- Absolute contraindications: Perforated eardrum, allergy to ingredients, G6PD deficiency in infants
- Dosing: 4 drops, 2-3x daily for ≤7 days (warm bottle before use)
- Onset: Pain relief starts within 5-10 minutes (lidocaine) and lasts 1-2 hours
This comprehensive guide examines how Otigo ear drops work for ear infections, detailing its unique dual mechanism of action combining the antibacterial properties of ciprofloxacin with the pain-relieving effects of lidocaine. We'll explore how Otigo targets both infection and discomfort simultaneously, explain why its localized delivery directly to the ear canal enhances effectiveness, and reveal what patients can realistically expect from this combined treatment approach.
How Otigo Ear Drops Work
Otigo targets pain receptors in the middle ear without passing through the eardrum
Phenazone (40mg/g)
- Action: Non-opioid analgesic that inhibits prostaglandin synthesis
- Effect: Reduces inflammation/swelling in Eustachian tubes
- Onset: 30-60 minutes (longer-acting)
Lidocaine (10mg/g)
- Action: Blocks sodium channels in nerve fibers
- Effect: Numbs pain receptors in ear canal/middle ear
- Onset: 5-10 minutes (fast-acting but short duration)
Approved Uses of Otigo Ear Drops
Otigo is indicated for local symptomatic treatment of:
| Condition | Symptoms | Typical Duration |
|---|---|---|
| Acute otitis media | Earache, fever, muffled hearing | 3-7 days |
| Post-flu otitis | Persistent ear pain after respiratory infection | 5-10 days |
| Barotraumatic otitis | Pain from pressure changes (flying/diving) | 1-3 days |
Who Can Use Otigo Ear Drops Safely?
Approved For:
- Adults & children with intact tympanic membranes
- Pregnant/breastfeeding women (minimal systemic absorption)
- Patients with mild-moderate ear pain (VAS score 3-7/10)
Special Considerations:
- Elderly: No dose adjustment needed
- Athletes: Lidocaine may trigger anti-doping alerts
- G6PD deficiency: Safe in patients >3 months old
Who Should Avoid Otigo Ear Drops?
| Contraindication | Reason | Risk Level |
|---|---|---|
| Perforated eardrum | May cause ototoxicity (inner ear damage) | Absolute |
| Allergy to phenazone/lidocaine | Risk of anaphylaxis | Absolute |
| Infants <3 months with G6PD deficiency | Risk of methemoglobinemia (blood disorder) | Absolute |
| Active ear discharge | Possible tympanic perforation | Caution |
- Vertigo (spinning sensation)
- Hearing loss/tinnitus
- Facial numbness
- Rash/swelling around ear
Proper Application Technique
Step-by-Step Guide
- Warm the bottle between hands for 1-2 minutes (prevents vertigo from cold drops)
- Tilt head with affected ear upward
- Gently pull earlobe backward and upward (straightens ear canal)
- Instill 4 drops (2-3x daily max)
- Maintain position for 3-5 minutes
- Wipe excess with clean tissue (don't insert cotton buds)
Important Tips
- Use within 6 months of opening
- Avoid contact with eyes/nose
- Never share bottles between patients
- Store at room temperature (15-25°C)
FAQs
Can Otigo be used for swimmer's ear (otitis externa)?
No - Otigo is specifically formulated for middle ear conditions (otitis media). For outer ear infections:
- Use antibiotic/antifungal ear drops
- Keep ear dry during treatment
- Avoid inserting objects (e.g., cotton buds)
Misuse in otitis externa may worsen infection.
Why must the eardrum be intact for Otigo use?
If the tympanic membrane is perforated:
- Drops may reach the inner ear, causing vertigo
- Risk of ototoxicity (hearing damage from lidocaine)
- Potential interference with healing
Your doctor can check eardrum integrity with an otoscope.
What should I do if Otigo doesn't relieve my ear pain?
If pain persists after 2-3 days of proper use:
- Stop using Otigo and consult a doctor
- You may need antibiotics for bacterial infection
- Persistent pain could indicate serious conditions requiring different treatment
Never exceed the recommended 7-day treatment period without medical supervision.
 | Authored by Nabeel |
Medical Content Manager
Nabeel is a co-founder, and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
 | Reviewed by Dr. Feroz (GMC:7921697) |
Medical Doctor
Dr. Feroz is a GMC-registered doctor and a medical reviewer at Chemist Doctor. He oversees acute condition and urgent care guidance.
 | Approved by Usman |
Medical Director
Usman is a co-founder, and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 12 August 2025
Next Review: 14 February 2026
Published on: 11 August 2025
Last Updated: 12 August 2025
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