Epiduo Gel
Epiduo Gel is a prescription-only topical treatment containing two active ingredients: adapalene (0.1%) and benzoyl peroxide (2.5%). This combination gel works through complementary mechanisms to treat inflammatory and non-inflammatory acne vulgaris. Clinically proven for patients aged 9 years and above, Epiduo Gel is typically applied once daily at bedtime to clean, dry skin affected by acne. This medication is available through Chemist Doctor's regulated online service following a consultation with UK-licensed clinicians.
You must complete a short online consultation so that our prescriber can ensure that the treatment is suitable for you.
| Product Name: | Epiduo Gel 0.1% / 2.5% |
|---|---|
| Manufacturer: | Galderma UK Limited |
| Active Ingredient: | Adapalene 0.1% w/w, Benzoyl Peroxide 2.5% w/w |
| Administration: | Topical gel (external use only) |
| Presentation: | White to very pale yellow opaque gel |
| Available Strengths: | 0.1% adapalene / 2.5% benzoyl peroxide only |
| Prescription Required: | Yes |
| Dosage: | Once daily at bedtime |
| Suitable for pregnancy? | No |
| Use with alcohol: | No direct interaction |
| Package Size | Presentation | Current Price | |
|---|---|---|---|
| 15g tube | Plastic tube with screw-cap | £25.99 | |
| 30g tube | Plastic tube with screw-cap | £34.99 | |
| 60g pump | White pump with snap-on cap | £49.99 | |
| Epiduo Gel is a prescription acne treatment that combines adapalene and benzoyl peroxide. It works by unclogging pores, reducing inflammation, and killing acne-causing bacteria. Please consult with your healthcare provider before starting this medication. | |||
| This treatment requires an online consultation for review by our medical team. The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective. | |||
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Table of Contents
- What is Epiduo Gel?
- What is Epiduo Gel Used For?
- Before Using Epiduo Gel
- Epiduo Gel Contraindications
- Special Population Considerations
- Epiduo Gel and Other Medicines
- Pregnancy & Breastfeeding
- Driving & Machine Operation
- Epiduo Gel Ingredients
- How to Use Epiduo Gel
- Epiduo Gel Dosage Guidelines
- Administration Instructions
- Missed Dose Management
- Overdose Information
- Epiduo Gel Side Effects
- How to Store Epiduo Gel
- Epiduo Gel Pack Information
- Epiduo Gel FAQs
What is Epiduo Gel?
Epiduo Gel is a prescription-only topical treatment specifically formulated for acne vulgaris. It contains two complementary active ingredients that work synergistically to address multiple aspects of acne pathogenesis according to NHS acne treatment guidelines:
Active Ingredients & Drug Class
- Adapalene (0.1% w/w): A third-generation retinoid that selectively binds to retinoic acid receptors (RAR-β and RAR-γ) in the skin. Unlike earlier retinoids, adapalene has reduced skin irritation while maintaining efficacy.
- Benzoyl Peroxide (2.5% w/w): An organic peroxide with potent antimicrobial activity against Cutibacterium acnes (formerly Propionibacterium acnes) and mild keratolytic (skin peeling) properties.
Mechanism of Action Explained Simply
Think of acne development as a three-step process: clogged pores, bacterial overgrowth, and inflammation. Epiduo Gel addresses all three:
- Unclogging pores: Adapalene normalises the skin cell lifecycle, preventing dead cells from accumulating and blocking hair follicles.
- Bacterial control: Benzoyl peroxide releases oxygen that kills acne-causing bacteria and prevents resistance development.
- Reducing inflammation: Both ingredients have anti-inflammatory properties that calm existing acne lesions and prevent new ones from becoming severely inflamed.
Biological Pathway Explanation
At a cellular level, adapalene modulates gene expression in keratinocytes (skin cells), normalising their differentiation and reducing hyperkeratinisation. It also inhibits toll-like receptor 2 (TLR-2) activation, reducing inflammatory cytokine production. Benzoyl peroxide generates free radicals that oxidise bacterial proteins and lipids, effectively killing C. acnes while also promoting gentle exfoliation of the stratum corneum (skin's outermost layer).
What is Epiduo Gel Used For?
Epiduo Gel is specifically indicated for the topical treatment of acne vulgaris when comedones, papules and pustules are present. It is approved for use in patients aged 9 years and above as detailed in the official product information.
Important Safety Notice:
Discontinue immediately and seek medical help if you experience:
- Throat tightness or difficulty breathing (allergic reaction)
- Swelling of eyes/face/lips/tongue
- Widespread hives or itching
- Feeling faint or dizzy
Approved Indications
| Condition | Acne Types Treated | Typical Patient Profile |
|---|---|---|
| Mild to moderate acne vulgaris | Comedonal, inflammatory, and mixed acne | Adolescents and adults with 10-50 inflammatory lesions |
| Moderate acne vulgaris | Papules, pustules, mild nodules | Patients with failed response to single-agent therapy |
Target Patient Populations
- Adolescents (12-18 years): First-line combination therapy for inflammatory acne
- Adults (18+ years): Persistent or late-onset acne
- Pediatric (9-11 years): Early-onset acne under medical supervision
- Patients with treatment-resistant acne: Those who haven't responded adequately to single-ingredient treatments
Before Using Epiduo Gel
Proper assessment before starting treatment ensures safety and effectiveness. Our clinicians will evaluate the following during your consultation:
Medical History Assessment Checklist
- Previous acne treatments and responses
- History of skin conditions (eczema, rosacea, psoriasis)
- Known allergies, especially to retinoids, benzoyl peroxide, or sunscreen components
- Current pregnancy status or plans to become pregnant
- History of photosensitivity disorders
- Previous experience with topical medications causing severe irritation
Skin Evaluation Requirements
While our online consultation doesn't involve physical examination, you'll need to:
- Provide clear photos of affected areas (optional but recommended)
- Describe your acne type, severity, and distribution
- Report any current skincare routine and products used
- Note any areas of broken skin, sunburn, or eczema
Pre-treatment Considerations
- Discontinue use of other acne products 2-3 days before starting Epiduo Gel
- Avoid waxing, laser treatments, or chemical peels on treatment areas
- Consider starting treatment when you can limit sun exposure
- Have a gentle, non-comedogenic moisturiser available to manage potential dryness
Epiduo Gel Contraindications
Absolute Contraindications (DO NOT USE)
- Pregnancy or planning pregnancy
- Known hypersensitivity to adapalene, benzoyl peroxide, or any excipient
- Application to broken skin, cuts, abrasions, or sunburned skin
- Use on eczema or other inflammatory skin conditions in the treatment area
Relative Contraindications (Use with Caution)
| Condition | Risk Level | Recommendation |
|---|---|---|
| Severe acne with nodules/cysts | High | May require oral medication instead/in addition |
| History of severe contact dermatitis | Moderate | Consider patch test before full application |
| Concurrent use of other topical retinoids | High | Discontinue other retinoids before starting |
| Excessive sun exposure unavoidable | Moderate | Strict sunscreen use required, consider delaying treatment |
Special Population Considerations
Elderly Patients (65+ years)
While acne is less common in this population, Epiduo Gel can be used with caution. Age-related skin thinning and decreased barrier function may increase sensitivity. Consider:
- Starting with application every other day
- Using smaller amounts of gel
- More frequent moisturiser application
- Close monitoring for excessive dryness or irritation
Pediatric & Adolescent Patients (9-18 years)
Epiduo Gel is approved for ages 9 years and above. Special considerations include:
- Parental supervision for application in younger patients
- Education about proper application technique
- Monitoring for proper adherence to treatment regimen
- Counseling about realistic expectations and treatment duration
Patients with Skin of Colour
May be at increased risk of post-inflammatory hyperpigmentation (dark marks). Recommendations:
- Strict sun protection with broad-spectrum SPF 30+
- Consider starting with lower frequency (every other day)
- Monitor for excessive irritation which can worsen hyperpigmentation
- May benefit from concurrent use of pigment-correcting agents (after acne is controlled)
Epiduo Gel and Other Medicines
High-Risk Medication Combinations
| Medication Type | Interaction Risk | Recommendation |
|---|---|---|
| Other topical retinoids (tretinoin, isotretinoin gel) | High - Increased irritation | Avoid concurrent use |
| Other benzoyl peroxide products | High - Excessive dryness/irritation | Avoid concurrent use |
| Topical antibiotics (clindamycin, erythromycin) | Low to Moderate | May be used together under medical supervision |
| Oral retinoids (isotretinoin capsules) | High - Extreme dryness risk | Generally not recommended together |
| Photosensitising medications (tetracyclines, fluoroquinolones) | Moderate - Increased photosensitivity | Extra sun protection required |
Topical Product Compatibility
Avoid using with:
- Astringents, toners containing alcohol
- Physical/chemical exfoliants (scrubs, peels)
- Harsh cleansers (sulfate-based)
- Products with high concentrations of salicylic acid, glycolic acid, or other acids
Safe to use with (after waiting 20-30 minutes):
- Gentle, non-comedogenic moisturisers
- Mineral-based sunscreens (titanium dioxide/zinc oxide)
- Basic cleansers without active ingredients
Pregnancy & Breastfeeding
Absolute Contraindication in Pregnancy
EPIDUO GEL MUST NOT BE USED DURING PREGNANCY OR IF PLANNING PREGNANCY. Adapalene is a retinoid with potential teratogenic effects. Discontinue treatment immediately if you become pregnant and consult your doctor.
Pregnancy Precautions
- Contraception requirement: Females of childbearing potential must use effective contraception during treatment and for at least 1 month after discontinuation
- Pre-treatment testing: Pregnancy test recommended before starting treatment in women of childbearing potential
- Discontinuation protocol: Stop treatment immediately if pregnancy occurs and seek medical advice
Breastfeeding Considerations
- Epiduo Gel can be used during breastfeeding with precautions
- Avoid application to the chest area to prevent accidental infant exposure
- Wash hands thoroughly after application before handling infant
- Monitor infant for any signs of irritation if accidental contact occurs
- Consult healthcare provider before use during breastfeeding
Driving & Machine Operation
Epiduo Gel has no known effect on the ability to drive or operate machinery. The treatment is topical and systemic absorption is minimal, so it does not cause drowsiness, dizziness, or impaired judgment.
Important Considerations
- If accidental eye contact occurs, it may cause temporary irritation affecting vision - rinse immediately with plenty of water
- If severe skin irritation develops, discomfort could potentially distract from focused tasks
- No restrictions apply for driving or operating machinery when using Epiduo Gel as directed
Epiduo Gel Ingredients
Active Ingredients (Per gram of gel)
- Adapalene: 1 mg (0.1% w/w) - Retinoid that normalises skin cell turnover
- Benzoyl Peroxide (as benzoyl peroxide hydrol): Equivalent to 25 mg anhydrous benzoyl peroxide (2.5% w/w) - Antimicrobial and mild keratolytic agent
Excipients (Inactive Ingredients) & Their Functions
| Ingredient | Function | Allergen Note |
|---|---|---|
| Propylene glycol (E1520) | Humectant and solvent - maintains gel consistency | Contains 40 mg/g (4% w/w) |
| Poloxamer | Surfactant - helps even distribution of active ingredients | Generally well tolerated |
| Docusate sodium | Wetting agent - enhances skin penetration | Rarely causes irritation |
| Polysorbate 80 (E433) | Emulsifier - stabilises the gel formulation | Can cause allergic reactions |
| Disodium edetate | Chelating agent - preserves product stability | Generally safe |
| Glycerol | Moisturiser - reduces potential dryness | Hypoallergenic |
| Simulgel 600 PHA | Gelling agent - provides appropriate viscosity | Contains acrylamide copolymer |
| Purified water | Vehicle - base of the gel formulation | Non-allergenic |
Allergen Warnings
- Polysorbates: May cause allergic reactions in sensitive individuals
- Propylene glycol: Can cause irritation in individuals with sensitivity
- Perfume/ Fragrance: Epiduo Gel is fragrance-free
How to Use Epiduo Gel
Proper application technique is crucial for effectiveness and minimizing side effects.
Step-by-Step Application Guide
- Cleanse: Gently wash affected areas with a mild, non-medicated cleanser and pat dry with a clean towel. Avoid harsh scrubbing.
- Wait: Ensure skin is completely dry before application (wait 20-30 minutes after washing).
- Dispense: Squeeze a pea-sized amount (approximately 0.5g) onto clean fingertip for each facial area (forehead, each cheek, chin). For larger areas, use proportionally more gel but avoid excessive application.
- Apply: Dot gel onto affected areas, then spread evenly in a thin film. Avoid applying directly from tube to face.
- Avoid sensitive areas: Keep away from eyes, eyelids, lips, nostrils, mouth, and any areas of broken skin, cuts, or abrasions.
- Wash hands: Immediately after application, wash hands thoroughly with soap and water.
- Moisturise (if needed): Wait 20-30 minutes, then apply a non-comedogenic moisturiser if experiencing dryness.
Application Frequency Schedule
| Week | Frequency | Tips for Adjustment Period |
|---|---|---|
| Week 1-2 | Every other day or every third day | Allows skin to adapt; reduces initial irritation |
| Week 3-4 | Once daily (if tolerated) | Apply at bedtime for optimal tolerance |
| Week 5+ | Once daily (maintenance) | Consistent application yields best results |
Epiduo Gel Dosage Guidelines
Standard Dosage Recommendations
| Patient Group | Recommended Dosage | Maximum Application Area |
|---|---|---|
| Adults & Adolescents (12+ years) | Apply once daily at bedtime | Full face, chest, back, shoulders |
| Children (9-11 years) | Apply once daily at bedtime | Limited to affected areas only |
| Elderly (65+ years) | Apply once daily at bedtime | May start with every other day application |
Treatment Duration & Expectations
- Initial improvement: 4-8 weeks of regular use
- Significant improvement: 8-12 weeks of consistent application
- Maintenance phase: Continue treatment as long as acne persists; acne may recur if stopped prematurely
- Maximum duration: No defined limit; can be used long-term under medical supervision
Dosage Adjustment Scenarios
| Situation | Dosage Adjustment | Duration |
|---|---|---|
| Initial skin irritation | Reduce to every other day or every third day | 2-4 weeks until tolerance improves |
| Excessive dryness | Apply moisturiser 20-30 minutes after gel | Throughout treatment as needed |
| Complete clearance | May reduce to 2-3 times weekly | Maintenance phase |
Administration Instructions
Detailed Application Technique
- Preparation: Wash hands before handling tube. Cleanse treatment area gently and pat dry completely.
- Dispensing: For facial acne, use approximately 0.5g (pea-sized amount) total for entire face. For chest/back, use amount approximately the size of a 10p coin for each area.
- Distribution: Dot gel onto fingertips first, then apply to affected areas using gentle, even strokes. Do not rub vigorously.
- Coverage: Apply to entire affected area, not just individual spots. This helps prevent new acne formation.
- Avoidance zones: Maintain 1-2cm distance from eyes, lips, nostrils. Do not apply to neck unless specifically affected and directed by clinician.
- Post-application: Allow gel to dry completely (5-10 minutes) before applying other products or dressing.
Tips for Specific Body Areas
- Face: Apply after evening skincare routine, before bed
- Chest/Back: May require assistance for application to ensure even coverage
- Shoulders: Avoid areas where backpack straps or clothing may cause friction
What to Avoid During Treatment
- Do not apply to wet skin
- Do not cover treated areas with occlusive dressings or bandages
- Do not use with abrasive cleansers, scrubs, or loofahs
- Do not apply immediately after shaving
- Avoid hot water on treated areas
Missed Dose Management
Time-Based Guidance
| Time Since Missed Dose | Action | Next Scheduled Dose |
|---|---|---|
| Less than 12 hours | Apply as soon as remembered | Continue with regular schedule |
| More than 12 hours | Skip missed dose | Apply next dose at usual time |
| Completely forgotten until next day | Skip missed dose | Apply next dose at usual time |
Important Rules
- NEVER apply double dose to make up for missed application
- Do not increase frequency beyond once daily
- If unsure, err on side of skipping rather than over-applying
- Consistency is more important than perfect timing
If Multiple Doses Are Missed
If you haven't used Epiduo Gel for several days:
- Resume treatment with your next scheduled dose
- Consider starting with every other day application for 1 week if more than 5 days missed
- Contact your clinician if you're unsure about restarting regimen
Overdose Information
Topical Overapplication
Applying more Epiduo Gel than recommended will not improve results faster and may cause:
- Severe skin redness, burning, or stinging
- Excessive dryness, peeling, or flaking
- Swelling or blistering at application site
- Increased risk of skin irritation and contact dermatitis
Management of Topical Overdose
- Gently wash off excess gel with mild cleanser and lukewarm water
- Apply a soothing, fragrance-free moisturiser
- Discontinue use until skin returns to normal (typically 2-7 days)
- When restarting, reduce frequency (every other day) and amount used
- Contact your clinician if severe irritation persists beyond 48 hours
Accidental Ingestion
If Epiduo Gel is accidentally swallowed:
- Do not induce vomiting unless directed by medical professional
- Rinse mouth thoroughly with water
- Drink a glass of water or milk
- Seek immediate medical attention or contact Poison Control
- Bring the medication package to show healthcare providers
Accidental Eye Contact
- Immediately rinse affected eye with plenty of lukewarm water for 15-20 minutes
- Keep eyelids open during rinsing
- Seek medical attention if irritation persists after rinsing
- Do not rub the eye
Epiduo Gel Side Effects
Serious Allergic Reactions - Seek Immediate Help
Stop using Epiduo Gel and get emergency medical help if you experience: throat tightness, swelling of eyes/face/lips/tongue, difficulty breathing, feeling faint, or widespread hives/itching. Frequency of these serious reactions is unknown but requires immediate attention.
Side Effects by Frequency
| Frequency | Side Effects | Management |
|---|---|---|
| Very Common (≥1 in 10) | Dry skin, skin burning sensation, skin irritation, skin redness (erythema), scaling | Usually mild, peaks at week 2-4, improves with continued use. Use moisturiser. |
| Common (≥1 in 100 to <1 in 10) | Local skin rash (irritative contact dermatitis), itching (pruritus), sunburn | Reduce application frequency, use sunscreen, consult clinician if persistent. |
| Uncommon (≥1 in 1,000 to <1 in 100) | Skin pain (stinging), application site burn, blisters (vesicles) | Temporarily stop treatment, consult clinician before resuming. |
| Rare (≥1 in 10,000 to <1 in 1,000) | Swelling of face/eyelid, allergic contact dermatitis, skin discolouration | Discontinue use and consult clinician immediately. |
| Frequency Unknown | Difficulty breathing, throat tightness, severe allergic reactions | Stop use and seek emergency medical attention. |
Initial Adjustment Period ("Purge Phase")
Many patients experience temporary worsening during weeks 2-6 as treatment brings underlying acne to surface. This is normal and indicates the medication is working. Characteristics:
- Increased number of visible lesions
- Existing lesions may become more inflamed temporarily
- Typically resolves by week 6-8
- Continue treatment unless severe irritation occurs
Long-term Side Effects Management
- Persistent dryness: Apply non-comedogenic moisturiser 20-30 minutes after gel
- Sun sensitivity: Use broad-spectrum SPF 30+ daily, avoid excessive sun exposure
- Excessive peeling: Reduce application frequency, avoid physical exfoliation
- Eye irritation: Ensure careful application away from eye area
Reporting Side Effects
Report any side effects to your clinician or via the UK Yellow Card Scheme at www.mhra.gov.uk/yellowcard. Reporting helps improve drug safety information.
How to Store Epiduo Gel
Storage Conditions
- Temperature: Store below 25°C. Do not freeze.
- Container: Keep tube or pump tightly closed when not in use
- Location: Store in original container, away from direct sunlight and heat sources
- Access: Keep out of sight and reach of children and pets
- Moisture: Avoid storing in humid areas like bathrooms
Shelf Life & Expiry
| Condition | Duration | Action Required |
|---|---|---|
| Unopened, stored correctly | Until expiry date on carton/tube | Do not use after expiry date |
| After first opening | 6 months maximum | Discard after 6 months even if not finished |
| Expired product | N/A | Do not use; dispose of properly |
Disposal Protocol
- Do not dispose via wastewater or household waste
- Return unused or expired medication to your pharmacy for proper disposal
- Some local authorities offer medicine take-back schemes
- Proper disposal helps protect the environment
Travel Considerations
- Keep in original packaging with pharmacy label
- Carry in hand luggage if flying (under 100ml liquid restrictions apply)
- Protect from extreme temperatures during transport
- Consider climate of destination (hot climates may affect stability)
Epiduo Gel Pack Information
Available Pack Sizes
| Presentation | Size | Container Type | Product Code/PL Number |
|---|---|---|---|
| Epiduo 0.1%/2.5% Gel | 5g | White plastic tube with screw-cap | PL 20117/0006 |
| Epiduo 0.1%/2.5% Gel | 15g | White plastic tube with screw-cap | PL 20117/0006 |
| Epiduo 0.1%/2.5% Gel | 30g | White plastic tube with screw-cap | PL 20117/0006 |
| Epiduo 0.1%/2.5% Gel | 60g | White pump with snap-on cap | PL 20117/0006 |
Marketing Authorisation Details
- Marketing Authorisation Holder: Galderma UK Limited, Evergreen House North, Grafton Place, London NW1 2DX, United Kingdom
- Manufacturer: Laboratories Galderma, ZJ – Montdésir - 74540 Alby sur Chéran - France
- Legal Classification: POM (Prescription Only Medicine)
- UK Product Licence Number: PL 20117/0006
- Last Leaflet Revision: August 2024
Product Identification
- Appearance: White to very pale yellow opaque gel
- Odour: Characteristic odour of benzoyl peroxide
- Consistency: Smooth, spreadable gel
- Packaging: Amber protection not required as formulation is stable in white opaque tubes
Where Can I Buy Epiduo Gel Online in the UK
Secure Epiduo Gel Prescription & Next-Day Delivery Service
Order Epiduo Gel with confidence through our UK-registered medical prescribers, who review all requests within 4 working hours. We guarantee same-day prescription approval for eligible patients and dispatch orders placed before 3pm for next-day tracked delivery.
Our Epiduo Gel service combines competitive pricing with strict adherence to MHRA safety standards, ensuring your medication is dispensed through GPhC-registered pharmacies. Every purchase includes discreet packaging and a GDPR-compliant consultation process.
Our clinical team ensures:
- Comprehensive medical history review
- Acne type and severity assessment
- Drug interaction checks
- Personalised application guidance
Always consult your GP before starting acne treatment. Not recommended for children under 9 or those with known hypersensitivity to ingredients.
Epiduo Gel (Adapalene/Benzoyl Peroxide) FAQs
How long does it take for Epiduo Gel to work?
Initial improvement is typically seen within 4-8 weeks of regular use, with optimal results after 12 weeks of consistent application. Many patients experience a temporary "purge phase" during weeks 2-6 where acne may appear worse as treatment brings underlying clogged pores to the surface. This is normal and indicates the medication is working effectively.
Can I use moisturiser with Epiduo Gel?
Yes, using a non-comedogenic, fragrance-free moisturiser is recommended, especially if you experience dryness or peeling. Apply the moisturiser 20-30 minutes after applying Epiduo Gel to allow proper absorption. Look for moisturisers labeled "oil-free," "non-comedogenic," or specifically formulated for acne-prone skin.
Is Epiduo Gel safe for sensitive skin?
Epiduo Gel can be used on sensitive skin with proper precautions. Start with application every other day or every third day to allow your skin to adapt. Use a pea-sized amount for the entire face, and always apply to completely dry skin. If irritation persists, consult your clinician who may recommend reducing frequency or using additional moisturising products.
Can I wear makeup while using Epiduo Gel?
Yes, but wait at least 20-30 minutes after applying Epiduo Gel before applying makeup. Choose non-comedogenic, oil-free makeup products that won't clog pores. Always remove makeup thoroughly before applying Epiduo Gel in the evening. Mineral-based makeup is often a good choice as it's less likely to cause irritation.
What should I do if Epiduo Gel causes burning or stinging?
Mild burning or stinging during the first few weeks is common as your skin adjusts. If it's severe or persistent, reduce application frequency to every other day. Ensure you're applying to completely dry skin (wait 20-30 minutes after washing), using only a pea-sized amount for the entire face, and avoiding sensitive areas. If symptoms continue, consult your clinician.
Can I use Epiduo Gel on my body acne?
Yes, Epiduo Gel can be used on chest, back, and shoulder acne. Use approximately a 10p coin-sized amount for each larger body area. Body skin may be less sensitive than facial skin, but still start with every other day application if treating large areas. Avoid applying to areas where clothing causes friction.
How does Epiduo Gel compare to other acne treatments?
Epiduo Gel combines two proven acne treatments in one formulation, offering complementary mechanisms of action. Compared to single-ingredient treatments, it addresses more aspects of acne pathogenesis simultaneously. Unlike some topical antibiotics, benzoyl peroxide doesn't lead to bacterial resistance. Compared to oral treatments, it has fewer systemic side effects but requires consistent topical application.
Can teenagers use Epiduo Gel?
Yes, Epiduo Gel is approved for use in adolescents and children aged 9 years and above. It's commonly prescribed for teenage acne. Parental supervision is recommended for younger teens to ensure proper application technique and adherence. Education about realistic expectations and the importance of sun protection is particularly important for this age group.
What happens if I stop using Epiduo Gel?
If you stop Epiduo Gel treatment, acne may gradually return as the underlying causes persist. For maintenance after clear skin is achieved, some patients reduce frequency to 2-3 times weekly rather than stopping completely. Always consult your clinician before discontinuing treatment, and never stop abruptly if experiencing side effects without medical advice.
Can I use Epiduo Gel with other acne products?
Generally, avoid using other acne products containing retinoids, benzoyl peroxide, or salicylic acid simultaneously with Epiduo Gel, as this increases irritation risk. Some clinicians may prescribe topical antibiotics (like clindamycin) to use in the morning with Epiduo at night. Always consult your clinician before combining treatments.
Does Epiduo Gel bleach hair or fabrics?
Yes, benzoyl peroxide can bleach hair, clothing, towels, and bedding. Avoid contact with coloured fabrics and hair. Apply to clean, dry skin and wait until completely absorbed before contact with fabrics. Use white towels and pillowcases if concerned about bleaching. Wash hands thoroughly after application to prevent accidental bleaching.
How should I apply sunscreen with Epiduo Gel?
Apply Epiduo Gel at night. In the morning, cleanse gently and apply a broad-spectrum SPF 30+ sunscreen. Mineral sunscreens with zinc oxide or titanium dioxide are often less irritating for acne-prone skin. Reapply every 2 hours if exposed to sun. Sun protection is crucial as Epiduo increases sun sensitivity.
What if I get Epiduo Gel in my eyes?
If Epiduo Gel gets in your eyes, immediately rinse with plenty of lukewarm water for 15-20 minutes, keeping eyelids open. Seek medical attention if irritation persists. To prevent this, apply carefully avoiding the eye area, and wash hands immediately after application.
Can men use Epiduo Gel when shaving?
Yes, but avoid applying Epiduo Gel immediately after shaving when skin may be irritated. Shave in the morning if applying Epiduo at night, or skip application on shaved areas that day. Use a sharp, clean razor and shaving cream for sensitive skin. Consider electric shavers which may cause less irritation.
Is Epiduo Gel available over the counter?
No, Epiduo Gel is a prescription-only medicine (POM) in the UK. You need a consultation with a healthcare professional who will assess your suitability. At Chemist Doctor, our UK-registered clinicians provide online consultations, and if appropriate, can prescribe Epiduo Gel for delivery to your door.
Medical Content Manager
Nabeel is a co-founder, and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
Medical Doctor
Dr. Talal is a GMC registered doctor and medical reviewer at Chemist Doctor. He ensures clinical accuracy and reliability across health content.
Medical Director
Usman is a co-founder, and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 01 January 2026
Next Review: 01 June 2026
Published on: 01 January 2026
Last Updated: 01 January 2026
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Can I return prescription medication?
No. UK law prohibits returns of dispensed prescription treatments for safety reasons.
How does Pay in 3 by Klarna UK work?
Pay in 3 by Klarna UK allows you to split your purchase into 3 equal payments. The first payment is made at checkout, with the remaining two payments automatically collected every 30 days. There are no interest or fees when you pay on time. Klarna UK is a fully regulated credit provider.
"Epiduo cleared my persistent acne in 10 weeks after nothing else worked. The initial dryness was manageable with moisturiser."
"Great service, discreet delivery. The consultation was thorough. My skin is much better after 3 months of use."
"Clinician explained exactly what to expect. The purge phase was rough but worth sticking with. My skin hasn't looked this good in years."
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