Wegovy Injections

What is Wegovy?

Wegovy is a prescription medication containing the active substance semaglutide, presented as a solution for injection in a pre-filled pen. It belongs to a class of medicines called glucagon-like peptide-1 (GLP-1) receptor agonists.

Mechanism of Action

Wegovy works through multiple mechanisms:

• Appetite regulation: Acts on receptors in the brain to increase satiety signals and reduce hunger
• Gastric emptying: Slows down food movement from stomach to intestine
• Blood sugar control: Enhances insulin secretion and reduces glucagon production

Think of Wegovy as a tool that helps reset your body's appetite regulation system, making it easier to feel satisfied with smaller portions and reduce cravings.

What is Wegovy Used For?

Wegovy is indicated for weight management as an adjunct to:

• Reduced-calorie diet
• Increased physical activity

Approved Patient Groups

Before Using Wegovy

Essential considerations before initiating treatment:

Medical History Assessment

• Thyroid disease history (especially medullary thyroid carcinoma)
• Pancreatitis history (acute or chronic)
• Gastrointestinal disorders (gastroparesis)
• Diabetic retinopathy or macular oedema
• Renal impairment

Required Baseline Tests

1. Thyroid function tests (TSH, calcitonin)
2. Pancreatic enzymes (amylase, lipase)
3. Renal function (eGFR, creatinine)
4. Liver function (ALT, AST)
5. Cardiovascular assessment

Wegovy Contraindications

Absolute contraindications where Wegovy must not be used:

Absolute Contraindications

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Hypersensitivity to semaglutide or excipients
• Severe gastrointestinal disease (gastroparesis)

Special Warnings

Special Population Considerations

Elderly Patients (≥75 years)

• Limited clinical experience
• Increased risk of dehydration - monitor fluid intake

Renal Impairment

• Mild-moderate impairment: No dose adjustment
• Severe impairment: Use with caution

Hepatic Impairment

• Limited data available
• Use with caution in severe impairment

Wegovy and Other Medicines

Significant interactions requiring monitoring:

High-Risk Combinations

• Insulin/Sulfonylureas: Increased hypoglycaemia risk (dose reduction needed)
• Oral contraceptives: Reduced efficacy - use barrier methods

Absorption Interactions

Due to delayed gastric emptying:

• Take oral medications 1 hour before Wegovy injection
• Particularly critical for:
  • Antibiotics
  • Thyroid medications
  • Blood thinners (warfarin)

Pregnancy & Breastfeeding

Pregnancy

• Contraindicated during pregnancy
• Discontinue immediately if pregnancy occurs
• Use effective contraception during treatment

Breastfeeding

• Unknown if semaglutide passes into breast milk
• Not recommended during breastfeeding
• Discuss alternatives with your doctor

Driving & Machine Operation

• No direct impairment of driving ability
• Caution advised due to possible:
  • Dizziness
  • Hypoglycaemia (when combined with other agents)
  • Fatigue
• Do not drive if experiencing warning signs of low blood sugar

Wegovy Ingredients

Active Substance

• Semaglutide

Excipients

Sodium Content

• Less than 1 mmol sodium (23 mg) per dose
• Essentially 'sodium-free'

How to Use Wegovy FlexTouch Pen

Preparation Steps

1. Wash hands thoroughly
2. Remove pen cap and inspect solution (should be clear and colorless)
3. Attach new needle
4. Prime the pen to remove air bubbles

Injection Technique

• Sites: Abdomen, thighs, or upper arms
• Angle: 90° insertion
• Rotation: Change injection site weekly
• Duration: Hold dose button until dose counter shows 0

Post-Injection Protocol

1. Apply light pressure if bleeding occurs
2. Carefully replace outer needle shield
3. Unscrew and dispose of needle in sharps container
4. Replace pen cap

Wegovy Dosage Guidelines

Standard Titration Schedule

Dose Adjustment Criteria

• Each dose increase requires at least 4 weeks at current dose
• Maximum dose: 2.4 mg weekly
• Do not increase dose if experiencing significant side effects

Administration Instructions

Step-by-step injection guide:

Dose Selection

1. Check pen label for correct dose strength
2. Each pen delivers only one fixed dose
3. Never attempt to split doses

Injection Process

1. Insert needle at 90° angle into clean skin
2. Press and hold dose button completely
3. Keep needle inserted until dose counter returns to 0
4. Withdraw needle gently

Post-Injection Care

• Check dose window for confirmation of complete delivery
• Do not rub injection site
• Rotate sites weekly to prevent lipodystrophy

Missed Dose Management

General Principles

• Do NOT double doses
• Minimum 5 days between doses

Time-Based Guidance

Overdose Information

Symptoms

• Severe nausea/vomiting
• Hypoglycaemia
• Dehydration
• Abdominal pain

Management

1. Seek immediate medical attention
2. Bring medication packaging
3. Symptomatic treatment:
   • IV fluids for dehydration
   • Glucose for hypoglycaemia
   • Antiemetics if severe vomiting

Possible Side Effects

Very Common (more than 1 in 10 people)

• Nausea
• Diarrhoea
• Vomiting
• Abdominal pain
• Constipation

Common (1 in 10 to 1 in 100 people)

• Decreased appetite
• Indigestion (dyspepsia)
• Bloating
• Burping
• Reflux or heartburn
• Hair loss
• Fatigue
• Injection site reactions

Serious Side Effects

How to Store Wegovy

Unused Pens

• Refrigerate at 2-8°C
• Do not freeze
• Keep in original carton

In-Use Pens

• May store at ≤30°C
• Use within 56 days of first use
• Discard after expiration date

Disposal

• Dispose needles in sharps container
• Return unused pens to pharmacy
• Never dispose in household waste

Pack Information

Pack Sizes

• 1 pre-filled pen (single dose)
• 3 pre-filled pens (three doses)

Components

• Pre-filled pen (single dose)
• Needles NOT included
• Instructions for use

Appearance

• Clear, colorless solution
• Pre-filled disposable pen
• Color-coded pen based on dose strength

Where Can I Buy Wegovy Online in the UK