Zoely Tablets
Zoely is a modern combined oral contraceptive pill containing two active hormones: nonnegestrol acetate (a progestogen) and estradiol (an oestrogen). Unlike some traditional contraceptive pills that use ethinylestradiol, Zoely contains estradiol, which is identical to the natural oestrogen produced by the ovaries. This 28-day regimen includes 24 active white tablets and 4 inactive yellow placebo tablets, designed to provide effective contraception while potentially offering improved tolerability for some women.
You must complete a short online consultation so that our prescriber can ensure that the treatment is suitable for you.
| Product Name: | Zoely |
|---|---|
| Manufacturer: | Theramex Ireland Limited |
| Active Ingredients: | Nonnegestrol acetate (2.5mg) and Estradiol (1.5mg) |
| Administration: | Oral tablet |
| Presentation: | 28 film-coated tablets (24 active white + 4 placebo yellow) |
| Available Strengths: | 2.5mg nonnegestrol acetate / 1.5mg estradiol |
| Prescription Required: | Yes |
| Dosage: | One tablet daily |
| Suitable for pregnancy? | No |
| Use with alcohol: | Yes, but alcohol may affect pill-taking consistency |
| Strength | Package | Current Price | |
|---|---|---|---|
| 2.5mg/1.5mg | 28 tablets (1 month) | £24.99 | |
| 2.5mg/1.5mg | 84 tablets (3 months) | £69.99 | |
| 2.5mg/1.5mg | 168 tablets (6 months) | £134.99 | |
| Zoely is a combined contraceptive pill with natural estrogen. It belongs to the drug class of combined hormonal contraceptives (CHCs). Please consult with your healthcare provider before starting this medication. | |||
| This treatment requires an online consultation for review by our medical team. The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective. | |||
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Table of Contents
- What is Zoely?
- What is Zoely Used For?
- Before Using Zoely
- Zoely Contraindications
- Special Population Considerations
- Zoely and Other Medicines
- Pregnancy & Breastfeeding
- Driving & Machine Operation
- Zoely Ingredients
- How to Use Zoely
- Zoely Dosage Guidelines
- Administration Instructions
- Missed Dose Management
- Overdose Information
- Zoely Side Effects
- How to Store Zoely
- Zoely Pack Information
- Zoely FAQs
What is Zoely?
Zoely is a combined oral contraceptive pill containing two active hormonal ingredients: nonnegestrol acetate (2.5mg) and estradiol (1.5mg). It belongs to the drug class of combined hormonal contraceptives (CHCs), which work by providing both estrogen and progestogen to prevent pregnancy through multiple mechanisms.
Active Ingredients and Drug Class
Zoely contains:
- Nonnegestrol acetate: A progestogen derived from progesterone, similar to the hormone produced by ovaries during the menstrual cycle
- Estradiol: An oestrogen identical to the natural hormone produced by ovaries, unlike synthetic ethinylestradiol found in some other contraceptive pills
Mechanism of Action
Zoely works through three primary mechanisms to prevent pregnancy:
- Ovulation inhibition: Suppresses the release of eggs from the ovaries
- Cervical mucus thickening: Creates a thicker cervical mucus barrier that impedes sperm movement
- Endometrial changes: Alters the uterine lining to make it less receptive to implantation
Think of Zoely as creating a multi-layered defense system: it stops egg release, blocks sperm entry, and makes the uterine environment inhospitable for potential implantation.
Biological Pathway Explanation
Zoely works by providing steady levels of hormones that mimic the luteal phase of the menstrual cycle. The estradiol component suppresses follicle-stimulating hormone (FSH), preventing follicular development, while the nonnegestrol acetate suppresses luteinizing hormone (LH), preventing ovulation. This hormonal feedback creates a stable environment that doesn't trigger the natural ovulation cycle.
What is Zoely Used For?
Zoely is indicated for contraception (prevention of pregnancy) in women of reproductive age. It is one of the most reliable reversible contraceptive methods when taken correctly.
Approved Indications
Zoely is approved for:
- Prevention of pregnancy in women requiring hormonal contraception
- Women seeking a combined contraceptive with natural estrogen (estradiol) rather than synthetic ethinylestradiol
Target Patient Populations
Zoely may be suitable for:
- Women aged 18-50 years (no efficacy/safety data in adolescents under 18)
- Women seeking reliable reversible contraception
- Women who prefer or better tolerate estradiol over ethinylestradiol
- Women without contraindications to combined hormonal contraceptives
CRITICAL SAFETY WARNING
Zoely, like all combined hormonal contraceptives, increases the risk of blood clots (venous thromboembolism). The risk is highest during the first year of use or when restarting after a 4+ week break. Seek immediate medical attention if you experience symptoms of blood clots, heart attack, or stroke (see Section 15 for symptoms).
Do not use Zoely if you have current or history of blood clots, certain cancers, severe liver disease, unexplained vaginal bleeding, or migraine with aura.
Before Using Zoely
Before starting Zoely, a thorough medical assessment is essential to ensure it's appropriate and safe for you.
Medical History Assessment Checklist
Your clinician will assess:
- Personal and family history of blood clots, heart conditions, or stroke
- History of migraine (particularly migraine with aura)
- Current or history of cancers (especially breast, genital organs, liver)
- Liver or gallbladder disease
- Diabetes with vascular complications
- High blood pressure, high cholesterol, or triglycerides
- Depression or other psychiatric conditions
- Unexplained vaginal bleeding
- Pregnancy or suspected pregnancy
- Allergies to ingredients
Required Baseline Evaluations
- Blood pressure measurement (mandatory before prescription)
- Weight and BMI calculation
- Review of family medical history (especially first-degree relatives)
- Discussion of lifestyle factors (smoking status particularly important)
- Depending on individual risk factors: additional tests may be recommended
Zoely Contraindications
Absolute Contraindications (Do Not Use)
- Current or history of blood clots (venous or arterial thrombosis)
- Known blood clotting disorders (e.g., Factor V Leiden, protein deficiencies)
- Current or history of heart attack, stroke, or angina
- Migraine with aura (current or history)
- Diabetes with vascular damage
- Very high blood pressure
- Severe liver disease or liver tumours
- Current or suspected breast cancer or genital organ cancer
- Unexplained vaginal bleeding
- Meningioma (current or history)
- Pancreatitis with high blood triglycerides
- Allergy to any ingredients
- Pregnancy or suspected pregnancy
Relative Contraindications (Use With Caution/Medical Supervision)
- Migraine without aura (monitor for changes)
- Mild to moderate hypertension (controlled)
- Mild liver impairment
- Gallbladder disease
- Diabetes without vascular complications
- Depression
- Crohn's disease or ulcerative colitis
- Systemic lupus erythematosus (SLE)
- Sickle cell anaemia
- Age over 35, especially if smoking
- Obesity (BMI ≥30 kg/m²)
- Family history of blood clots, heart disease, or breast cancer
Risk Stratification Table
| Risk Level | Conditions/Scenarios | Recommendation |
|---|---|---|
| High Risk | Multiple risk factors, smoking age 35+, migraine with aura, previous VTE | Alternative contraception recommended |
| Moderate Risk | Single risk factor (e.g., obesity, controlled hypertension), family history | May use with close monitoring |
| Low Risk | No risk factors, non-smoker, age under 35, normal BMI | Suitable candidate |
Special Population Considerations
Elderly Women
Zoely is not indicated for postmenopausal women. For women over 35:
- Increased risk of blood clots with age
- Smoking is an absolute contraindication in women over 35
- Require careful cardiovascular risk assessment
- May need to consider alternative contraception
Adolescents (Under 18)
No efficacy or safety data available for adolescents below 18 years. Not recommended for this age group.
Renal Impairment
No specific studies, but unlikely to affect Zoely metabolism. Use with caution in severe renal impairment.
Hepatic Impairment
Contraindicated in severe liver disease. Use with caution in mild to moderate impairment with regular monitoring.
Perioperative Patients
Discontinue Zoely 4-6 weeks before elective surgery or during prolonged immobilization due to increased thrombosis risk.
Zoely and Other Medicines
Several medicines can interact with Zoely, reducing its effectiveness or increasing side effects.
Medicines That Reduce Zoely Effectiveness
- Antiepileptics: Carbamazepine, phenytoin, phenobarbital, primidone, oxcarbazepine, topiramate, felbamate
- Antibiotics: Rifampicin, rifabutin (for tuberculosis)
- HIV medications: Ritonavir, efavirenz, nevirapine
- Hepatitis C treatments: Boceprevir, telaprevir
- Antifungals: Griseofulvin
- Pulmonary hypertension drugs: Bosentan
- Herbal supplements: St. John's wort
Timing Recommendations
If using interacting medications:
- Use additional barrier contraception (condoms) while taking interacting medicines
- Continue barrier method for 28 days after stopping interacting medicine
- Consult your clinician about alternative contraception if long-term interacting medication needed
Medicines Affected by Zoely
- Lamotrigine (antiepileptic) - Zoely may reduce its levels
- Laboratory tests - Zoely may affect some blood test results
Important Interaction Notes
Always inform all healthcare providers (doctors, dentists, pharmacists) that you're taking Zoely when prescribed any new medication.
Pregnancy & Breastfeeding
Pregnancy
Zoely is contraindicated during pregnancy. If you become pregnant while taking Zoely:
- Stop taking Zoely immediately
- Contact your doctor
- Use alternative contraception if not trying to conceive
Contraception Requirements
Zoely provides contraception only while taken correctly. If you stop to try to conceive:
- Wait for one natural menstrual period before trying to conceive
- This helps calculate accurate due dates
- Use barrier contraception during this waiting period
Breastfeeding
Not usually recommended during breastfeeding. Small amounts of hormones pass into breast milk. If considering Zoely while breastfeeding:
- Consult your doctor about risks vs benefits
- Consider progestogen-only contraceptives as often preferred during breastfeeding
- If using Zoely, monitor infant for any side effects
Postpartum Considerations
After childbirth:
- Can start Zoely between 21-28 days postpartum if not breastfeeding
- Increased thrombosis risk postpartum - careful risk assessment needed
- If starting after day 28, use barrier contraception for first 7 days
- If sexually active before starting, ensure not pregnant
Driving & Machine Operation
Zoely has no or negligible effect on your ability to drive and use machines.
Impairment Potential Assessment
Clinical studies show:
- No significant effect on cognitive function or reaction times
- No direct sedative effects
- Can be used safely when driving or operating machinery
Warning Signs to Watch For
Although Zoely doesn't directly impair driving, be aware of:
- Migraine or severe headaches (which could affect concentration)
- Visual disturbances (particularly if experiencing migraine with aura)
- Dizziness or lightheadedness (potential side effect)
- If experiencing these symptoms, avoid driving until resolved
Zoely Ingredients
Active Ingredients
- Nonnegestrol acetate: 2.5mg per white active tablet
- Estradiol (as hemihydrate): 1.5mg per white active tablet
- Yellow placebo tablets contain no active ingredients
Excipients (Inactive Ingredients)
White active tablet core:
- Lactose monohydrate (milk sugar) - filler
- Microcrystalline cellulose (E460) - binder
- Crospovidone (E1201) - disintegrant
- Talc (E553b) - glidant
- Magnesium stearate (E572) - lubricant
- Colloidal anhydrous silica - anti-caking agent
White active tablet coat:
- Poly(vinyl alcohol) (E1203) - coating polymer
- Titanium dioxide (E171) - colour/opacifier
- Macrogol 3350 - plasticizer
Yellow placebo tablets also contain iron oxide yellow and black (E172) for colour.
Allergen Warnings
- Contains lactose: Not suitable for lactose intolerance
- Contains no gluten
- Potential for hypersensitivity to any excipients
How to Use Zoely
Zoely comes in a 28-tablet blister pack: 24 white active tablets and 4 yellow placebo tablets.
Step-by-Step Administration
- Start with tablet #1 in top left corner of blister
- Attach day label: Use provided sticker matching your start day
- Take daily: One tablet at same time each day
- Follow arrows: Take white tablets first (24 days), then yellow tablets (4 days)
- Start new pack immediately after last yellow tablet
Starting Your First Pack
If no hormonal contraception in past month:
- Start on first day of menstrual period
- Contraception immediate - no additional protection needed
Switching from other combined contraceptive:
- Start Zoely day after last active tablet of current pill
- Or day after removing vaginal ring/patch
- No additional protection needed if switched correctly
Switching from progestogen-only methods:
- Start Zoely next day after stopping previous method
- Use additional barrier contraception for first 7 days
Zoely Dosage Guidelines
Standard Dosage Regimen
| Tablet Type | Number | Days | Hormonal Content |
|---|---|---|---|
| White active tablets | 24 tablets | Days 1-24 | 2.5mg nonnegestrol acetate + 1.5mg estradiol |
| Yellow placebo tablets | 4 tablets | Days 25-28 | No active ingredients |
Withdrawal Bleeding
Your period (withdrawal bleeding) typically occurs during the 4 yellow tablet days, starting 2-3 days after last white tablet.
Titration Schedule
No titration needed - start with full dose. The 24+4 regimen provides steady hormone levels throughout the cycle.
Administration Instructions
Daily Routine
- Take at approximately same time each day
- Can be taken with or without food
- Swallow whole with water - do not chew or crush
- Use day label on blister to track daily intake
Managing Common Scenarios
Vomiting or Severe Diarrhoea
- If vomiting within 3-4 hours of white tablet: Take another white tablet ASAP
- If severe diarrhoea: Similar to missed tablet - follow missed dose guidance
- Vomiting after yellow tablet: No action needed (placebo tablets)
Wanting to Delay Period
- Skip yellow tablets and start new pack immediately
- You may have spotting during second pack
- To restart periods: Take yellow tablets from second pack when desired
Changing Period Start Day
- Shorten yellow tablet days (never exceed 4 days)
- May have spotting during next pack
- Consult doctor if unsure about schedule changes
Missed Dose Management
Time-Based Guidance
Less than 24 hours late:
- Take missed tablet immediately
- Take next tablet at usual time
- Contraceptive protection maintained
24 hours or more late: Follow specific guidance based on when missed:
| When Missed | Action Required | Additional Protection |
|---|---|---|
| Days 1-7 | Take missed tablet immediately, continue pack | Barrier method for next 7 days |
| Days 8-17 | Take missed tablet immediately, continue pack | Only if missed >1 tablet |
| Days 18-24 | Option 1: Skip yellow tablets, start next pack Option 2: Take yellow tablets up to 3 days | If not taken correctly previous 7 days |
Missed Yellow Placebo Tablets
No action needed - discard missed yellow tablets. Contraceptive protection unaffected.
Overdose Information
Symptoms of Overdose
- Nausea and vomiting
- Vaginal bleeding
- No reports of serious harm from acute overdose
Management Protocol
- No specific antidote exists
- Symptomatic treatment if needed
- Medical supervision for significant symptoms
- If child ingests: Seek medical advice
Emergency Actions
If concerned about overdose:
- Contact your doctor or pharmacist
- In emergency, visit A&E or call 999
- Take packaging/leaflet to show medical staff
Zoely Side Effects
Like all medicines, Zoely can cause side effects, although not everyone experiences them.
Frequency-Based Categorisation
Very Common (≥1 in 10)
- Acne
- Changes to menstrual periods (absence or irregularity)
Common (≥1 in 100 to <1 in 10)
- Decreased interest in sex, depression/depressed mood, mood changes
- Headache or migraine
- Nausea
- Heavy menstrual periods, breast pain, pelvic pain
- Weight gain
Uncommon (≥1 in 1,000 to <1 in 100)
- Increased appetite, fluid retention (oedema)
- Hot flushes
- Swollen abdomen
- Increased sweating, hair loss, itching, dry/oily skin
- Heaviness in limbs
- Breast changes, vaginal dryness, premenstrual syndrome
- Irritability
- Increased liver enzymes
Rare (≥1 in 10,000 to <1 in 1,000)
- Blood clots in veins or arteries (see below)
- Decreased appetite, increased interest in sex
- Attention disturbances
- Eye dryness, contact lens intolerance
- Dry mouth
- Skin pigmentation changes, excessive hair growth
- Vaginal discomfort
- Gallbladder disease
SERIOUS SIDE EFFECTS - SEEK IMMEDIATE MEDICAL ATTENTION
Blood clots (thromboembolism) - symptoms include:
- Leg: Swelling, pain, warmth, colour changes
- Lung: Sudden breathlessness, chest pain, coughing blood
- Heart: Chest pain/pressure radiating to arm/jaw, sweating, nausea
- Stroke: Sudden weakness/numbness, speech/vision problems, severe headache
- Eye: Sudden vision loss or blurring
Other serious reactions:
- Severe allergic reaction (swelling face/tongue, breathing difficulty)
- Severe abdominal pain (possible liver problems)
- Meningioma symptoms: Vision changes, hearing loss, persistent headaches
- Severe depression or suicidal thoughts
Managing Common Side Effects
Many side effects improve after 2-3 months as your body adjusts. Consult your doctor if:
- Side effects persist beyond 3 months
- Side effects are severe or concerning
- You experience irregular bleeding beyond first few months
How to Store Zoely
Storage Conditions
- No special storage requirements
- Store in original packaging
- Keep out of sight and reach of children
Expiry Date
Do not use after expiry date printed on blister and carton (EXP date).
Disposal Protocol
- Do not dispose via wastewater or toilet
- Return unused tablets to pharmacy
- Follow local disposal regulations
- Proper disposal protects aquatic environment from hormonal contamination
Zoely Pack Information
What's in the Pack
- 1 blister strip of 28 film-coated tablets
- 24 white active tablets + 4 yellow placebo tablets
- Day label stickers for tracking
- Patient information leaflet
Pack Size Variations
| Pack Size | Tablet Count | Duration |
|---|---|---|
| Standard pack | 28 tablets | 1 month |
| Multipack | 84 tablets | 3 months |
| Multipack | 168 tablets | 6 months |
Tablet Identification
- White active tablets: Round, white, coded "ne" on both sides
- Yellow placebo tablets: Round, yellow, coded "p" on both sides
Where Can I Buy Zoely Online in the UK
Secure Zoely Prescription & Next-Day Delivery Service
Order Zoely with confidence through our UK-registered medical prescribers, who review all requests within 4 working hours. We guarantee same-day prescription approval for eligible patients and dispatch orders placed before 3pm for next-day tracked delivery.
Our Zoely service combines competitive pricing with strict adherence to MHRA safety standards, ensuring your medication is dispensed through GPhC-registered pharmacies. Every purchase includes discreet packaging and a GDPR-compliant consultation process.
Our clinical team ensures:
- Comprehensive medical history review
- Blood pressure assessment
- Contraindication screening
- Drug interaction checks
- Personalised contraception guidance
Always consult your GP before starting any hormonal contraception. Not recommended for women with certain medical conditions including migraine with aura, history of blood clots, or breast cancer.
Zoely (Nonnegestrol acetate/Estradiol) FAQs
How effective is Zoely at preventing pregnancy?
When taken correctly, Zoely is over 99% effective at preventing pregnancy. This means fewer than 1 in 100 women will get pregnant in a year when using Zoely perfectly. With typical use (occasional missed tablets), the effectiveness is around 91% according to NHS guidelines.
How is Zoely different from other contraceptive pills?
Zoely contains estradiol, which is identical to the natural oestrogen produced by ovaries, unlike many pills that contain synthetic ethinylestradiol. It also uses a 24+4 regimen (24 active pills, 4 placebos) rather than the traditional 21+7. According to the official product information, some women may experience different side effect profiles with Zoely compared to other combined pills.
Can I take Zoely if I get migraines?
If you have migraine with aura (visual disturbances, numbness, speech problems before headache), you must NOT take Zoely. If you have migraine without aura, you can take Zoely but should stop immediately and consult your doctor if you develop aura symptoms. Migraine with aura significantly increases stroke risk with combined contraceptives.
What should I do if I miss a period while taking Zoely?
If you've taken all tablets correctly and haven't had vomiting/diarrhoea or taken interacting medicines, missing a period occasionally is normal with Zoely. Continue taking your pills. If you miss two consecutive periods, or if you've missed tablets, take a pregnancy test and consult your doctor before starting the next pack.
How soon does Zoely start working?
If started on the first day of your period, Zoely works immediately. If started at any other time, use additional contraception (condoms) for the first 7 days. When switching from other hormonal contraceptives, follow specific switching instructions to ensure continuous protection.
Can Zoely help with acne or painful periods?
Zoely may help improve acne for some women, though acne is also listed as a possible side effect. Many combined contraceptives can help with menstrual symptoms, but Zoely is specifically licensed only for contraception, not for acne or period pain treatment. Discuss other contraceptive options with your doctor if these are primary concerns.
What if I'm sick (vomit) after taking a tablet?
If you vomit within 3-4 hours of taking a white active tablet, take another white tablet as soon as possible. If it's been more than 4 hours, follow the missed tablet guidance. For yellow placebo tablets, vomiting doesn't require any action as they contain no active ingredients.
Can I drink alcohol while taking Zoely?
Yes, Zoely doesn't interact with alcohol. However, alcohol can affect judgment about taking pills regularly. Also, heavy drinking increases liver strain, and Zoely is processed by the liver, so excessive alcohol consumption is not recommended.
Does Zoely protect against sexually transmitted infections (STIs)?
No. Zoely only prevents pregnancy. It provides NO protection against HIV/AIDS or other sexually transmitted infections. Use condoms to reduce STI risk, especially with new partners or if either partner has other sexual partners.
How long after stopping Zoely can I get pregnant?
Fertility typically returns quickly after stopping Zoely. Many women ovulate within 2-4 weeks. It's recommended to have one natural period before trying to conceive to help calculate accurate due dates. There's no evidence Zoely affects future fertility.
Can I take Zoely if I'm over 35?
Yes, if you're healthy, non-smoking, and have no cardiovascular risk factors. However, blood clot risk increases with age, so careful assessment is needed. If you're over 35 AND smoke, Zoely and all combined contraceptives are contraindicated.
What if I want to stop having periods altogether?
You can skip the yellow placebo tablets and go straight to a new pack to delay your period. However, you may experience breakthrough bleeding. While some women use combined pills continuously to stop periods, this should be discussed with your doctor as Zoely is licensed for the 24+4 regimen.
Does Zoely cause weight gain?
Weight gain is listed as a common side effect (affecting up to 1 in 10 users). However, clinical trials show minimal average weight change. Individual responses vary - some women gain weight, some lose, most stay stable. Monitor your weight and discuss concerns with your doctor.
Can I take Zoely if I have lactose intolerance?
No. Zoely contains lactose monohydrate. If you have lactose intolerance, you should not take Zoely. Inform your doctor about lactose intolerance so they can prescribe a lactose-free contraceptive alternative.
What should I do if I think I'm having side effects?
For mild side effects, continue taking Zoely as many improve after 2-3 months. For concerning or persistent side effects, consult your doctor or pharmacist. For serious side effects (blood clot symptoms, severe allergic reaction, etc.), seek immediate medical attention. You can also report side effects via the MHRA Yellow Card Scheme.
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Medical Content Manager
Nabeel is a co-founder, and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
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Dr. Talal is a GMC registered doctor and medical reviewer at Chemist Doctor. He ensures clinical accuracy and reliability across health content.
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Usman is a co-founder, and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 18 December 2025
Next Review: 20 June 2026
Published on: 18 December 2025
Last Updated: 18 December 2025
Getting your medication is quick and easy with our simple 4-step process:
Complete Online Consultation
Fill out our medical questionnaire (takes 5-10 minutes). Our UK-registered clinicians review your health information to ensure Zoely is safe and appropriate for you.
Clinician Review
Within 24 hours (usually faster), a clinician reviews your consultation. They may approve your prescription or contact you for more information if needed.
Prescription & Payment
If approved, you'll receive a prescription and payment request. Once payment is confirmed, our pharmacy team prepares your order.
Discreet Delivery
Your Zoely is packaged discreetly and dispatched. Choose standard (2-3 days) or next-day delivery. You'll receive tracking information.
What does the online consultation involve?
You'll answer questions about your medical history and current health to ensure safe prescribing. Honest responses are vital for your safety.
How do I reorder medication?
Use the login details emailed after your first order to access your account and reorder.
How does the secure chat portal work?
Clinicians may contact you via your account's chat portal to discuss your treatment. Respond securely within your account.
At Chemist Doctor, we respect your privacy and ensure complete discretion at every step.
Discreet Packaging Guarantee
All Zoely orders are shipped in plain, unmarked packaging with no indication of contents. The sender name is "Chemist Doctor" with no reference to medication or contraception.
Data Security Measures
End-to-end encryption for all personal and medical data, GDPR-compliant data protection protocols, and secure servers with regular security audits.
GP Communication Policies
We operate under NHS guidelines for shared care. We may write to your GP with your consent, or you can choose to keep treatment private from your GP.
Anonymous Billing
Credit card statements show a neutral descriptor with no reference to medications or contraception.
Will my GP be informed about my order?
Only with your consent. We recommend updating your GP directly for seamless care, but you can choose to keep treatment private.
We offer reliable delivery options to suit your needs:
| Service Type | Delivery Speed | Order Cut-off | Carrier |
|---|---|---|---|
| Standard Delivery | 2-3 business days | No cut-off | Royal Mail |
| Premium Next-Day Delivery | Next business day | 3 PM weekdays | Royal Mail 24 |
| Saturday Delivery | Saturday morning | Friday 12pm | Royal Mail Special Delivery |
Next-day delivery guarantee applies to orders approved before 3 PM to these regions:
- England
- Scotland
- Wales
- Northern Ireland
Service Restrictions: We currently cannot deliver to: Republic of Ireland, Continental Europe, USA, or Canada
Is packaging discreet?
Yes. All orders are shipped in plain, unmarked packaging via tracked courier services.
Do I need to stay home for delivery?
No. You'll receive a tracking number to monitor your parcel's progress.
Do you deliver on weekends or bank holidays?
Deliveries occur Monday–Friday only. We do not ship on weekends or UK bank holidays.
What should I do if my order hasn't arrived?
Use your tracking number to locate the parcel or contact our support team for assistance.
Can I receive delivery updates via SMS?
Yes. Provide your mobile number at checkout for courier updates. We will not use it for marketing purposes.
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How long do refunds take to process?
Card payments: Refunds appear in 3–5 days.
Klarna payments: Refunds are processed through Klarna and will be adjusted across your remaining instalments.
Why was my order declined?
Declined orders are not charged. Card authorisations release funds within 3–5 days (contact your bank for details).
Can I return prescription medication?
No. UK law prohibits returns of dispensed prescription treatments for safety reasons.
How does Pay in 3 by Klarna UK work?
Pay in 3 by Klarna UK allows you to split your purchase into 3 equal payments. The first payment is made at checkout, with the remaining two payments automatically collected every 30 days. There are no interest or fees when you pay on time. Klarna UK is a fully regulated credit provider.
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Zoely Film-Coated Tablets
Zoely is a modern combined oral contraceptive pill containing two active hormones: nonnegestrol acetate (a progestogen) and estradiol (an oestrogen). Unlike some traditional contraceptive pills that use ethinylestradiol, Zoely contains estradiol, which is identical to the natural oestrogen produced by the ovaries. This 28-day regimen includes 24 active white tablets and 4 inactive yellow placebo tablets, designed to provide effective contraception while potentially offering improved tolerability for some women.
You must complete a short online consultation so that our prescriber can ensure that the treatment is suitable for you.
| Product Name: | Zoely |
|---|---|
| Manufacturer: | Theramex Ireland Limited |
| Active Ingredients: | Nonnegestrol acetate (2.5mg) and Estradiol (1.5mg) |
| Administration: | Oral tablet |
| Presentation: | 28 film-coated tablets (24 active white + 4 placebo yellow) |
| Available Strengths: | 2.5mg nonnegestrol acetate / 1.5mg estradiol |
| Prescription Required: | Yes |
| Dosage: | One tablet daily |
| Suitable for pregnancy? | No |
| Use with alcohol: | Yes, but alcohol may affect pill-taking consistency |
| Strength | Package | Current Price | |
|---|---|---|---|
| 2.5mg/1.5mg | 28 tablets (1 month) | £24.99 | |
| 2.5mg/1.5mg | 84 tablets (3 months) | £69.99 | |
| 2.5mg/1.5mg | 168 tablets (6 months) | £134.99 | |
| Zoely is a combined contraceptive pill with natural estrogen. It belongs to the drug class of combined hormonal contraceptives (CHCs). Please consult with your healthcare provider before starting this medication. | |||
| This treatment requires an online consultation for review by our medical team. The decision to supply the specific treatment and quantity requested will be based on whether our medical team are satisfied that it will be safe, appropriate, and effective. | |||
Swipe left or right to view more information
Table of Contents
- What is Zoely?
- What is Zoely Used For?
- Before Using Zoely
- Zoely Contraindications
- Special Population Considerations
- Zoely and Other Medicines
- Pregnancy & Breastfeeding
- Driving & Machine Operation
- Zoely Ingredients
- How to Use Zoely
- Zoely Dosage Guidelines
- Administration Instructions
- Missed Dose Management
- Overdose Information
- Zoely Side Effects
- How to Store Zoely
- Zoely Pack Information
- Zoely FAQs
Key Takeaways
- Zoely is a combined contraceptive pill containing natural estrogen (estradiol) and progestogen (nonnegestrol acetate)
- It offers reliable contraception when taken correctly, with a 24+4 day regimen (24 active pills, 4 placebo pills)
- Contains estradiol identical to natural ovarian hormone rather than synthetic ethinylestradiol
- Like all combined hormonal contraceptives, it slightly increases blood clot risk, especially in first year of use
- Not suitable during pregnancy, breastfeeding, or for women with certain medical conditions
- Available by prescription following online consultation with UK-registered clinician
What is Zoely?
Zoely is a combined oral contraceptive pill containing two active hormonal ingredients: nonnegestrol acetate (2.5mg) and estradiol (1.5mg). It belongs to the drug class of combined hormonal contraceptives (CHCs), which work by providing both estrogen and progestogen to prevent pregnancy through multiple mechanisms.
Active Ingredients and Drug Class
Zoely contains:
- Nonnegestrol acetate: A progestogen derived from progesterone, similar to the hormone produced by ovaries during the menstrual cycle
- Estradiol: An oestrogen identical to the natural hormone produced by ovaries, unlike synthetic ethinylestradiol found in some other contraceptive pills
Mechanism of Action
Zoely works through three primary mechanisms to prevent pregnancy:
- Ovulation inhibition: Suppresses the release of eggs from the ovaries
- Cervical mucus thickening: Creates a thicker cervical mucus barrier that impedes sperm movement
- Endometrial changes: Alters the uterine lining to make it less receptive to implantation
Think of Zoely as creating a multi-layered defense system: it stops egg release, blocks sperm entry, and makes the uterine environment inhospitable for potential implantation.
Biological Pathway Explanation
Zoely works by providing steady levels of hormones that mimic the luteal phase of the menstrual cycle. The estradiol component suppresses follicle-stimulating hormone (FSH), preventing follicular development, while the nonnegestrol acetate suppresses luteinizing hormone (LH), preventing ovulation. This hormonal feedback creates a stable environment that doesn't trigger the natural ovulation cycle.
What is Zoely Used For?
Zoely is indicated for contraception (prevention of pregnancy) in women of reproductive age. It is one of the most reliable reversible contraceptive methods when taken correctly.
Approved Indications
Zoely is approved for:
- Prevention of pregnancy in women requiring hormonal contraception
- Women seeking a combined contraceptive with natural estrogen (estradiol) rather than synthetic ethinylestradiol
Target Patient Populations
Zoely may be suitable for:
- Women aged 18-50 years (no efficacy/safety data in adolescents under 18)
- Women seeking reliable reversible contraception
- Women who prefer or better tolerate estradiol over ethinylestradiol
- Women without contraindications to combined hormonal contraceptives
⚠️ CRITICAL SAFETY WARNING
Zoely, like all combined hormonal contraceptives, increases the risk of blood clots (venous thromboembolism). The risk is highest during the first year of use or when restarting after a 4+ week break. Seek immediate medical attention if you experience symptoms of blood clots, heart attack, or stroke (see Section 15 for symptoms).
Do not use Zoely if you have current or history of blood clots, certain cancers, severe liver disease, unexplained vaginal bleeding, or migraine with aura.
Before Using Zoely
Before starting Zoely, a thorough medical assessment is essential to ensure it's appropriate and safe for you.
Medical History Assessment Checklist
Your clinician will assess:
- Personal and family history of blood clots, heart conditions, or stroke
- History of migraine (particularly migraine with aura)
- Current or history of cancers (especially breast, genital organs, liver)
- Liver or gallbladder disease
- Diabetes with vascular complications
- High blood pressure, high cholesterol, or triglycerides
- Depression or other psychiatric conditions
- Unexplained vaginal bleeding
- Pregnancy or suspected pregnancy
- Allergies to ingredients
Required Baseline Evaluations
- Blood pressure measurement (mandatory before prescription)
- Weight and BMI calculation
- Review of family medical history (especially first-degree relatives)
- Discussion of lifestyle factors (smoking status particularly important)
- Depending on individual risk factors: additional tests may be recommended
Zoely Contraindications
Absolute Contraindications (Do Not Use)
- Current or history of blood clots (venous or arterial thrombosis)
- Known blood clotting disorders (e.g., Factor V Leiden, protein deficiencies)
- Current or history of heart attack, stroke, or angina
- Migraine with aura (current or history)
- Diabetes with vascular damage
- Very high blood pressure
- Severe liver disease or liver tumours
- Current or suspected breast cancer or genital organ cancer
- Unexplained vaginal bleeding
- Meningioma (current or history)
- Pancreatitis with high blood triglycerides
- Allergy to any ingredients
- Pregnancy or suspected pregnancy
Relative Contraindications (Use With Caution/Medical Supervision)
- Migraine without aura (monitor for changes)
- Mild to moderate hypertension (controlled)
- Mild liver impairment
- Gallbladder disease
- Diabetes without vascular complications
- Depression
- Crohn's disease or ulcerative colitis
- Systemic lupus erythematosus (SLE)
- Sickle cell anaemia
- Age over 35, especially if smoking
- Obesity (BMI ≥30 kg/m²)
- Family history of blood clots, heart disease, or breast cancer
Risk Stratification Table
| Risk Level | Conditions/Scenarios | Recommendation |
|---|---|---|
| High Risk | Multiple risk factors, smoking age 35+, migraine with aura, previous VTE | Alternative contraception recommended |
| Moderate Risk | Single risk factor (e.g., obesity, controlled hypertension), family history | May use with close monitoring |
| Low Risk | No risk factors, non-smoker, age under 35, normal BMI | Suitable candidate |
Special Population Considerations
Elderly Women
Zoely is not indicated for postmenopausal women. For women over 35:
- Increased risk of blood clots with age
- Smoking is an absolute contraindication in women over 35
- Require careful cardiovascular risk assessment
- May need to consider alternative contraception
Adolescents (Under 18)
No efficacy or safety data available for adolescents below 18 years. Not recommended for this age group.
Renal Impairment
No specific studies, but unlikely to affect Zoely metabolism. Use with caution in severe renal impairment.
Hepatic Impairment
Contraindicated in severe liver disease. Use with caution in mild to moderate impairment with regular monitoring.
Perioperative Patients
Discontinue Zoely 4-6 weeks before elective surgery or during prolonged immobilization due to increased thrombosis risk.
Zoely and Other Medicines
Several medicines can interact with Zoely, reducing its effectiveness or increasing side effects.
Medicines That Reduce Zoely Effectiveness
- Antiepileptics: Carbamazepine, phenytoin, phenobarbital, primidone, oxcarbazepine, topiramate, felbamate
- Antibiotics: Rifampicin, rifabutin (for tuberculosis)
- HIV medications: Ritonavir, efavirenz, nevirapine
- Hepatitis C treatments: Boceprevir, telaprevir
- Antifungals: Griseofulvin
- Pulmonary hypertension drugs: Bosentan
- Herbal supplements: St. John's wort
Timing Recommendations
If using interacting medications:
- Use additional barrier contraception (condoms) while taking interacting medicines
- Continue barrier method for 28 days after stopping interacting medicine
- Consult your clinician about alternative contraception if long-term interacting medication needed
Medicines Affected by Zoely
- Lamotrigine (antiepileptic) - Zoely may reduce its levels
- Laboratory tests - Zoely may affect some blood test results
Important Interaction Notes
Always inform all healthcare providers (doctors, dentists, pharmacists) that you're taking Zoely when prescribed any new medication.
Pregnancy & Breastfeeding
Pregnancy
Zoely is contraindicated during pregnancy. If you become pregnant while taking Zoely:
- Stop taking Zoely immediately
- Contact your doctor
- Use alternative contraception if not trying to conceive
Contraception Requirements
Zoely provides contraception only while taken correctly. If you stop to try to conceive:
- Wait for one natural menstrual period before trying to conceive
- This helps calculate accurate due dates
- Use barrier contraception during this waiting period
Breastfeeding
Not usually recommended during breastfeeding. Small amounts of hormones pass into breast milk. If considering Zoely while breastfeeding:
- Consult your doctor about risks vs benefits
- Consider progestogen-only contraceptives as often preferred during breastfeeding
- If using Zoely, monitor infant for any side effects
Postpartum Considerations
After childbirth:
- Can start Zoely between 21-28 days postpartum if not breastfeeding
- Increased thrombosis risk postpartum - careful risk assessment needed
- If starting after day 28, use barrier contraception for first 7 days
- If sexually active before starting, ensure not pregnant
Driving & Machine Operation
Zoely has no or negligible effect on your ability to drive and use machines.
Impairment Potential Assessment
Clinical studies show:
- No significant effect on cognitive function or reaction times
- No direct sedative effects
- Can be used safely when driving or operating machinery
Warning Signs to Watch For
Although Zoely doesn't directly impair driving, be aware of:
- Migraine or severe headaches (which could affect concentration)
- Visual disturbances (particularly if experiencing migraine with aura)
- Dizziness or lightheadedness (potential side effect)
- If experiencing these symptoms, avoid driving until resolved
Zoely Ingredients
Active Ingredients
- Nonnegestrol acetate: 2.5mg per white active tablet
- Estradiol (as hemihydrate): 1.5mg per white active tablet
- Yellow placebo tablets contain no active ingredients
Excipients (Inactive Ingredients)
White active tablet core:
- Lactose monohydrate (milk sugar) - filler
- Microcrystalline cellulose (E460) - binder
- Crospovidone (E1201) - disintegrant
- Talc (E553b) - glidant
- Magnesium stearate (E572) - lubricant
- Colloidal anhydrous silica - anti-caking agent
White active tablet coat:
- Poly(vinyl alcohol) (E1203) - coating polymer
- Titanium dioxide (E171) - colour/opacifier
- Macrogol 3350 - plasticizer
Yellow placebo tablets also contain iron oxide yellow and black (E172) for colour.
Allergen Warnings
- Contains lactose: Not suitable for lactose intolerance
- Contains no gluten
- Potential for hypersensitivity to any excipients
How to Use Zoely
Zoely comes in a 28-tablet blister pack: 24 white active tablets and 4 yellow placebo tablets.
Step-by-Step Administration
- Start with tablet #1 in top left corner of blister
- Attach day label: Use provided sticker matching your start day
- Take daily: One tablet at same time each day
- Follow arrows: Take white tablets first (24 days), then yellow tablets (4 days)
- Start new pack immediately after last yellow tablet
Starting Your First Pack
If no hormonal contraception in past month:
- Start on first day of menstrual period
- Contraception immediate - no additional protection needed
Switching from other combined contraceptive:
- Start Zoely day after last active tablet of current pill
- Or day after removing vaginal ring/patch
- No additional protection needed if switched correctly
Switching from progestogen-only methods:
- Start Zoely next day after stopping previous method
- Use additional barrier contraception for first 7 days
Zoely Dosage Guidelines
Standard Dosage Regimen
| Tablet Type | Number | Days | Hormonal Content |
|---|---|---|---|
| White active tablets | 24 tablets | Days 1-24 | 2.5mg nonnegestrol acetate + 1.5mg estradiol |
| Yellow placebo tablets | 4 tablets | Days 25-28 | No active ingredients |
Withdrawal Bleeding
Your period (withdrawal bleeding) typically occurs during the 4 yellow tablet days, starting 2-3 days after last white tablet.
Titration Schedule
No titration needed - start with full dose. The 24+4 regimen provides steady hormone levels throughout the cycle.
Administration Instructions
Daily Routine
- Take at approximately same time each day
- Can be taken with or without food
- Swallow whole with water - do not chew or crush
- Use day label on blister to track daily intake
Managing Common Scenarios
Vomiting or Severe Diarrhoea
- If vomiting within 3-4 hours of white tablet: Take another white tablet ASAP
- If severe diarrhoea: Similar to missed tablet - follow missed dose guidance
- Vomiting after yellow tablet: No action needed (placebo tablets)
Wanting to Delay Period
- Skip yellow tablets and start new pack immediately
- You may have spotting during second pack
- To restart periods: Take yellow tablets from second pack when desired
Changing Period Start Day
- Shorten yellow tablet days (never exceed 4 days)
- May have spotting during next pack
- Consult doctor if unsure about schedule changes
Missed Dose Management
Time-Based Guidance
Less than 24 hours late:
- Take missed tablet immediately
- Take next tablet at usual time
- Contraceptive protection maintained
24 hours or more late: Follow specific guidance based on when missed:
| When Missed | Action Required | Additional Protection |
|---|---|---|
| Days 1-7 | Take missed tablet immediately, continue pack | Barrier method for next 7 days |
| Days 8-17 | Take missed tablet immediately, continue pack | Only if missed >1 tablet |
| Days 18-24 | Option 1: Skip yellow tablets, start next pack Option 2: Take yellow tablets up to 3 days | If not taken correctly previous 7 days |
Missed Yellow Placebo Tablets
No action needed - discard missed yellow tablets. Contraceptive protection unaffected.
Overdose Information
Symptoms of Overdose
- Nausea and vomiting
- Vaginal bleeding
- No reports of serious harm from acute overdose
Management Protocol
- No specific antidote exists
- Symptomatic treatment if needed
- Medical supervision for significant symptoms
- If child ingests: Seek medical advice
Emergency Actions
If concerned about overdose:
- Contact your doctor or pharmacist
- In emergency, visit A&E or call 999
- Take packaging/leaflet to show medical staff
Zoely Side Effects
Like all medicines, Zoely can cause side effects, although not everyone experiences them.
Frequency-Based Categorisation
Very Common (≥1 in 10)
- Acne
- Changes to menstrual periods (absence or irregularity)
Common (≥1 in 100 to <1 in 10)
- Decreased interest in sex, depression/depressed mood, mood changes
- Headache or migraine
- Nausea
- Heavy menstrual periods, breast pain, pelvic pain
- Weight gain
Uncommon (≥1 in 1,000 to <1 in 100)
- Increased appetite, fluid retention (oedema)
- Hot flushes
- Swollen abdomen
- Increased sweating, hair loss, itching, dry/oily skin
- Heaviness in limbs
- Breast changes, vaginal dryness, premenstrual syndrome
- Irritability
- Increased liver enzymes
Rare (≥1 in 10,000 to <1 in 1,000)
- Blood clots in veins or arteries (see below)
- Decreased appetite, increased interest in sex
- Attention disturbances
- Eye dryness, contact lens intolerance
- Dry mouth
- Skin pigmentation changes, excessive hair growth
- Vaginal discomfort
- Gallbladder disease
⚠️ SERIOUS SIDE EFFECTS - SEEK IMMEDIATE MEDICAL ATTENTION
Blood clots (thromboembolism) - symptoms include:
- Leg: Swelling, pain, warmth, colour changes
- Lung: Sudden breathlessness, chest pain, coughing blood
- Heart: Chest pain/pressure radiating to arm/jaw, sweating, nausea
- Stroke: Sudden weakness/numbness, speech/vision problems, severe headache
- Eye: Sudden vision loss or blurring
Other serious reactions:
- Severe allergic reaction (swelling face/tongue, breathing difficulty)
- Severe abdominal pain (possible liver problems)
- Meningioma symptoms: Vision changes, hearing loss, persistent headaches
- Severe depression or suicidal thoughts
Managing Common Side Effects
Many side effects improve after 2-3 months as your body adjusts. Consult your doctor if:
- Side effects persist beyond 3 months
- Side effects are severe or concerning
- You experience irregular bleeding beyond first few months
How to Store Zoely
Storage Conditions
- No special storage requirements
- Store in original packaging
- Keep out of sight and reach of children
Expiry Date
Do not use after expiry date printed on blister and carton (EXP date).
Disposal Protocol
- Do not dispose via wastewater or toilet
- Return unused tablets to pharmacy
- Follow local disposal regulations
- Proper disposal protects aquatic environment from hormonal contamination
Zoely Pack Information
What's in the Pack
- 1 blister strip of 28 film-coated tablets
- 24 white active tablets + 4 yellow placebo tablets
- Day label stickers for tracking
- Patient information leaflet
Pack Size Variations
| Pack Size | Tablet Count | Duration |
|---|---|---|
| Standard pack | 28 tablets | 1 month |
| Multipack | 84 tablets | 3 months |
| Multipack | 168 tablets | 6 months |
Tablet Identification
- White active tablets: Round, white, coded "ne" on both sides
- Yellow placebo tablets: Round, yellow, coded "p" on both sides
Where Can I Buy Zoely Online in the UK
Secure Zoely Prescription & Next-Day Delivery Service
Order Zoely with confidence through our UK-registered medical prescribers, who review all requests within 4 working hours. We guarantee same-day prescription approval for eligible patients and dispatch orders placed before 3pm for next-day tracked delivery.
Our Zoely service combines competitive pricing with strict adherence to MHRA safety standards, ensuring your medication is dispensed through GPhC-registered pharmacies. Every purchase includes discreet packaging and a GDPR-compliant consultation process.
Our clinical team ensures:
- Comprehensive medical history review
- Blood pressure assessment
- Contraindication screening
- Drug interaction checks
- Personalised contraception guidance
Always consult your GP before starting any hormonal contraception. Not recommended for women with certain medical conditions including migraine with aura, history of blood clots, or breast cancer.
Zoely (Nonnegestrol acetate/Estradiol) FAQs
How effective is Zoely at preventing pregnancy?
When taken correctly, Zoely is over 99% effective at preventing pregnancy. This means fewer than 1 in 100 women will get pregnant in a year when using Zoely perfectly. With typical use (occasional missed tablets), the effectiveness is around 91% according to NHS guidelines.
How is Zoely different from other contraceptive pills?
Zoely contains estradiol, which is identical to the natural oestrogen produced by ovaries, unlike many pills that contain synthetic ethinylestradiol. It also uses a 24+4 regimen (24 active pills, 4 placebos) rather than the traditional 21+7. According to the official product information, some women may experience different side effect profiles with Zoely compared to other combined pills.
Can I take Zoely if I get migraines?
If you have migraine with aura (visual disturbances, numbness, speech problems before headache), you must NOT take Zoely. If you have migraine without aura, you can take Zoely but should stop immediately and consult your doctor if you develop aura symptoms. Migraine with aura significantly increases stroke risk with combined contraceptives.
What should I do if I miss a period while taking Zoely?
If you've taken all tablets correctly and haven't had vomiting/diarrhoea or taken interacting medicines, missing a period occasionally is normal with Zoely. Continue taking your pills. If you miss two consecutive periods, or if you've missed tablets, take a pregnancy test and consult your doctor before starting the next pack.
How soon does Zoely start working?
If started on the first day of your period, Zoely works immediately. If started at any other time, use additional contraception (condoms) for the first 7 days. When switching from other hormonal contraceptives, follow specific switching instructions to ensure continuous protection.
Can Zoely help with acne or painful periods?
Zoely may help improve acne for some women, though acne is also listed as a possible side effect. Many combined contraceptives can help with menstrual symptoms, but Zoely is specifically licensed only for contraception, not for acne or period pain treatment. Discuss other contraceptive options with your doctor if these are primary concerns.
What if I'm sick (vomit) after taking a tablet?
If you vomit within 3-4 hours of taking a white active tablet, take another white tablet as soon as possible. If it's been more than 4 hours, follow the missed tablet guidance. For yellow placebo tablets, vomiting doesn't require any action as they contain no active ingredients.
Can I drink alcohol while taking Zoely?
Yes, Zoely doesn't interact with alcohol. However, alcohol can affect judgment about taking pills regularly. Also, heavy drinking increases liver strain, and Zoely is processed by the liver, so excessive alcohol consumption is not recommended.
Does Zoely protect against sexually transmitted infections (STIs)?
No. Zoely only prevents pregnancy. It provides NO protection against HIV/AIDS or other sexually transmitted infections. Use condoms to reduce STI risk, especially with new partners or if either partner has other sexual partners.
How long after stopping Zoely can I get pregnant?
Fertility typically returns quickly after stopping Zoely. Many women ovulate within 2-4 weeks. It's recommended to have one natural period before trying to conceive to help calculate accurate due dates. There's no evidence Zoely affects future fertility.
Can I take Zoely if I'm over 35?
Yes, if you're healthy, non-smoking, and have no cardiovascular risk factors. However, blood clot risk increases with age, so careful assessment is needed. If you're over 35 AND smoke, Zoely and all combined contraceptives are contraindicated.
What if I want to stop having periods altogether?
You can skip the yellow placebo tablets and go straight to a new pack to delay your period. However, you may experience breakthrough bleeding. While some women use combined pills continuously to stop periods, this should be discussed with your doctor as Zoely is licensed for the 24+4 regimen.
Does Zoely cause weight gain?
Weight gain is listed as a common side effect (affecting up to 1 in 10 users). However, clinical trials show minimal average weight change. Individual responses vary - some women gain weight, some lose, most stay stable. Monitor your weight and discuss concerns with your doctor.
Can I take Zoely if I have lactose intolerance?
No. Zoely contains lactose monohydrate. If you have lactose intolerance, you should not take Zoely. Inform your doctor about lactose intolerance so they can prescribe a lactose-free contraceptive alternative.
What should I do if I think I'm having side effects?
For mild side effects, continue taking Zoely as many improve after 2-3 months. For concerning or persistent side effects, consult your doctor or pharmacist. For serious side effects (blood clot symptoms, severe allergic reaction, etc.), seek immediate medical attention. You can also report side effects via the MHRA Yellow Card Scheme.
Related Guides
Medical Content Manager
Nabeel is a co-founder, and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
Medical Doctor
Dr. Talal is a GMC registered doctor and medical reviewer at Chemist Doctor. He ensures clinical accuracy and reliability across health content.
Medical Director
Usman is a co-founder, and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 18 March 2025
Next Review: 18 September 2025
Published on: 18 March 2025
Last Updated: 18 March 2025
Getting your medication is quick and easy with our simple 4-step process:
Complete Online Consultation
Fill out our medical questionnaire (takes 5-10 minutes). Our UK-registered clinicians review your health information to ensure Zoely is safe and appropriate for you.
Clinician Review
Within 24 hours (usually faster), a clinician reviews your consultation. They may approve your prescription or contact you for more information if needed.
Prescription & Payment
If approved, you'll receive a prescription and payment request. Once payment is confirmed, our pharmacy team prepares your order.
Discreet Delivery
Your Zoely is packaged discreetly and dispatched. Choose standard (2-3 days) or next-day delivery. You'll receive tracking information.
What does the online consultation involve?
You'll answer questions about your medical history and current health to ensure safe prescribing. Honest responses are vital for your safety.
How do I reorder medication?
Use the login details emailed after your first order to access your account and reorder.
How does the secure chat portal work?
Clinicians may contact you via your account's chat portal to discuss your treatment. Respond securely within your account.
At Chemist Doctor, we respect your privacy and ensure complete discretion at every step.
Discreet Packaging Guarantee
All Zoely orders are shipped in plain, unmarked packaging with no indication of contents. The sender name is "Chemist Doctor" with no reference to medication or contraception.
Data Security Measures
End-to-end encryption for all personal and medical data, GDPR-compliant data protection protocols, and secure servers with regular security audits.
GP Communication Policies
We operate under NHS guidelines for shared care. We may write to your GP with your consent, or you can choose to keep treatment private from your GP.
Anonymous Billing
Credit card statements show a neutral descriptor with no reference to medications or contraception.
Will my GP be informed about my order?
Only with your consent. We recommend updating your GP directly for seamless care, but you can choose to keep treatment private.
We offer reliable delivery options to suit your needs:
| Service Type | Delivery Speed | Order Cut-off | Carrier |
|---|---|---|---|
| Standard Delivery | 2-3 business days | No cut-off | Royal Mail |
| Premium Next-Day Delivery | Next business day | 3 PM weekdays | Royal Mail 24 |
| Saturday Delivery | Saturday morning | Friday 12pm | Royal Mail Special Delivery |
Next-day delivery guarantee applies to orders approved before 3 PM to these regions:
- England
- Scotland
- Wales
- Northern Ireland
Service Restrictions: We currently cannot deliver to: Republic of Ireland, Continental Europe, USA, or Canada
Is packaging discreet?
Yes. All orders are shipped in plain, unmarked packaging via tracked courier services.
Do I need to stay home for delivery?
No. You'll receive a tracking number to monitor your parcel's progress.
Do you deliver on weekends or bank holidays?
Deliveries occur Monday–Friday only. We do not ship on weekends or UK bank holidays.
What should I do if my order hasn't arrived?
Use your tracking number to locate the parcel or contact our support team for assistance.
Can I receive delivery updates via SMS?
Yes. Provide your mobile number at checkout for courier updates. We will not use it for marketing purposes.
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Declined orders are not charged. Card authorisations release funds within 3–5 days (contact your bank for details).
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No. UK law prohibits returns of dispensed prescription treatments for safety reasons.
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Pay in 3 by Klarna UK allows you to split your purchase into 3 equal payments. The first payment is made at checkout, with the remaining two payments automatically collected every 30 days. There are no interest or fees when you pay on time. Klarna UK is a fully regulated credit provider.
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