Clove Oil Side Effects: Complete Safety Guide
When Do Side Effects Start? How Long Do They Last? Timeline, Contraindications & Food Interactions
Key Takeaways: Clove Oil Side Effects
- Common local effects: Temporary skin irritation, dermatitis, lip swelling, mouth blistering.
- Onset: Usually within minutes of application if irritation occurs; systemic effects rare.
- Duration: Most local effects resolve within minutes to hours; dermatitis may last longer.
- Contraindications: Allergy to clove/eugenol/Peru balsam, teething infants, damaged gums, anticoagulant use.
- Food interaction: None direct, but avoid eating immediately after application to prevent swallowing.
Clove Oil is generally safe when used correctly, but like all medicines it can cause side effects. This guide explains what side effects may occur, when they start, how long they last, and who should avoid using it.
Important Medical Advice
If you experience severe allergic reactions (swelling of face, throat, difficulty breathing), stop use immediately and seek emergency help. For accidental swallowing of large amounts, go to A&E. Report any unexpected side effects to the Yellow Card Scheme.
Common Side Effects of Clove Oil
Based on the Patient Information Leaflet (PIL) and clinical reports, the following side effects may occur:
- Temporary skin irritation – redness, burning sensation at the application site.
- Dermatitis – rash, itching, flaking of skin around the mouth or fingers (if oil contacts skin).
- Swelling of the lips – due to contact with the oil.
- Blistering and swelling inside the mouth – if oil spreads to gums or cheeks.
- Sensitisation – repeated exposure may cause allergy to clove oil or eugenol.
Systemic side effects are very rare when used topically. However, ingesting large amounts can cause nausea, vomiting, liver damage, CNS depression, and methaemoglobinaemia.
🗒️ Note: The PIL states: "If you notice these or any other side effect not included above, stop use and tell your doctor or pharmacist."
When Do Clove Oil Side Effects Start?
Side effects from topical application usually appear within minutes of contact. For example:
- Local irritation/burning: Immediately to 5 minutes after application.
- Swelling/blistering: May develop within 15–30 minutes if oil spreads to sensitive tissues.
- Allergic dermatitis: Can appear hours later if skin contact occurs and you are sensitised.
- Systemic toxicity (if swallowed): Symptoms may start 30 minutes to 2 hours after ingestion.
How Long Do Clove Oil Side Effects Last?
The duration depends on the type and severity of the reaction:
- Mild irritation/burning: Fades within 30–60 minutes as the oil dilutes or is wiped away.
- Lip/mouth swelling: Usually resolves within a few hours; if persistent, seek medical advice.
- Dermatitis/rash: May last several days; treat with emollients and avoid further contact.
- Systemic effects (rare): Recovery after ingestion may take 24–48 hours with supportive care.
If you develop a persistent reaction, consult a pharmacist or doctor.
Side Effects Timeline
| Time after application | Possible side effects |
|---|---|
| 0–15 minutes | Local burning, irritation, immediate redness |
| 15 minutes – 2 hours | Swelling of lips, blistering, dermatitis if skin contact |
| 2–24 hours | Allergic contact dermatitis (if sensitised), delayed swelling |
| If ingested: 30 min – 2 h | Nausea, vomiting, dizziness, CNS depression |
| After 24 hours | Most local effects resolved; dermatitis may persist |
Contraindications
Do not use Clove Oil if:
- Allergy: You are allergic to clove oil, eugenol, or Peru balsam.
- Teething: For teething pain in children (use sugar‑free teething gel instead).
- Damaged gums: Diseased, bleeding, or broken gums – application may worsen irritation.
- Anticoagulant therapy: If you take warfarin or other blood thinners, consult a doctor (eugenol may increase bleeding risk).
- Infants under 2 years: Not recommended.
- Pregnancy/breastfeeding: Avoid unless advised by a healthcare professional.
Food Interactions
There are no known direct interactions between Clove Oil and food. However, to ensure the oil remains on the tooth for maximum effect, it is best to avoid eating or drinking for at least 30 minutes after application. This also reduces the chance of swallowing the oil, which could cause stomach irritation.
If you accidentally swallow a small amount with food, it is unlikely to cause harm, but if symptoms develop, seek advice.
Clove Oil Side Effects FAQs
Can Clove Oil cause burns in the mouth?
Yes, if it spreads to gums or cheeks it can cause blistering or swelling. Always apply only to the affected tooth with a cotton bud.
Is Clove Oil safe to use with warfarin?
Eugenol may increase the anticoagulant effect. Consult your doctor or pharmacist before using Clove Oil if you take warfarin.
What should I do if Clove Oil gets on my skin?
Wash the area with soap and water. If irritation persists, apply a soothing cream like hydrocortisone 1% (if appropriate) and seek advice.
Can Clove Oil cause an allergic reaction?
Yes, people allergic to clove oil, eugenol, or Peru balsam may experience rash, swelling, or difficulty breathing. Stop use immediately if symptoms occur.
How long does Clove Oil stay in your system?
If swallowed, eugenol is metabolised and eliminated within 4‑6 hours. Local effects on the mouth usually resolve within an hour.
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Clinical References & Sources
Medical Content Manager
Nabeel is a co‑founder and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up‑to‑date.
Medical Doctor
Dr. Feroz is a GMC‑registered doctor and a medical reviewer at Chemist Doctor. He oversees acute condition and urgent care guidance.
Medical Director
Usman is a co‑founder and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 27 February 2026
Next Review: 27 August 2026
Published on: 27 February 2026
Last Updated: 27 February 2026