How To Use Priligy Tablets: Complete Step-by-Step Dosage Guide
Table of Contents
- How to Take Priligy: Step-by-Step Usage Guide
- Priligy Dosage Guide: 30mg vs 60mg Tablets
- Who Should Use Priligy Tablets
- Who Should Not Use Priligy: Contraindications
- To Be Taken With Food: Meal Timing & Effects
- Taking Priligy Without Food: Considerations
- Special Conditions & Precautions
- Frequently Asked Questions
Learn the correct way to take Priligy tablets for premature ejaculation treatment, including optimal timing, dosage adjustments, food interactions, and important safety precautions for effective and safe use.
Key Takeaways
- Optimal Timing: Take 1-3 hours before anticipated sexual activity
- Dosage Flexibility: Start with 30mg, may increase to 60mg if needed
- Frequency Limit: Maximum once every 24 hours
- Hydration Important: Always take with a full glass of water
- Alcohol Avoidance: Do not consume alcohol with Priligy
- Medical Review: Consult doctor after 4 weeks or 6 doses
Priligy (dapoxetine) requires specific timing and administration techniques to maximise effectiveness while minimising potential side effects. Understanding the proper usage protocol is essential for achieving the best results from this premature ejaculation treatment.
How to Take Priligy: Step-by-Step Usage Guide
Following the correct administration procedure ensures Priligy works effectively while reducing the risk of side effects like dizziness or fainting.
Step 1: Preparation (1-3 Hours Before Activity)
Timing and Planning
- Anticipate Timing: Plan to take tablet 1-3 hours before anticipated sexual activity
- Check Hydration: Ensure you are well-hydrated before administration
- Environment: Choose a comfortable setting for administration
- Avoid Alcohol: Do not consume alcohol within 24 hours of taking Priligy
Step 2: Administration Process
Correct Tablet Taking Technique
- Water Preparation: Have at least one full glass (250ml) of water ready
- Swallow Whole: Do not chew, crush or break the tablet
- Full Glass: Take with a full glass of water to reduce fainting risk
- Position: Remain seated or lying down for first 30 minutes after taking
Step 3: Post-Administration Care
Monitoring and Activity
- Initial Rest: Avoid standing up quickly for first 30-60 minutes
- Side Effect Monitoring: Watch for dizziness, nausea, or lightheadedness
- Activity Limitation: Avoid driving or operating machinery if feeling dizzy
- Hydration Maintenance: Continue drinking water throughout the day
Important Administration Notes
⚠️ Frequency Warning
Do not take Priligy more than once every 24 hours. The medication is designed for on-demand use, not continuous daily dosing.
💧 Hydration Essential
Taking with a full glass of water is crucial to reduce the risk of fainting and orthostatic hypotension.
🚫 Alcohol Prohibition
Avoid alcohol completely when using Priligy as it significantly increases the risk of serious side effects.
Priligy Dosage Guide: 30mg vs 60mg Tablets
Priligy is available in two strengths, with specific guidelines for starting dose, titration, and maximum usage to ensure safe and effective treatment.
30mg Tablet
- Recommended for: Initial treatment for all new users
- Timing: 1-3 hours before sexual activity
- Effectiveness: Adequate for approximately 60-70% of users
- Side Effect Profile: Generally better tolerated than 60mg
- Duration: Effects last 4-6 hours
60mg Tablet
- Recommended for: If 30mg provides insufficient effect
- Timing: 1-3 hours before sexual activity
- Effectiveness: Provides stronger ejaculatory delay
- Side Effect Profile: Higher incidence of side effects
- Duration: Effects last 4-6 hours
Dosage Titration Schedule
| Treatment Week | Recommended Dose | Assessment Timing | Action Required |
|---|---|---|---|
| Weeks 1-2 | 30mg as needed | After 2-3 uses | Evaluate effectiveness and side effects |
| Week 3-4 | 30mg or 60mg | After 4-6 total doses | Medical review with healthcare provider |
| Month 2-3 | Optimal dose determined | Every 4-6 uses | Continue or adjust based on response |
| 6 Months | Re-evaluation needed | Formal medical review | Determine ongoing treatment need |
Who Should Use Priligy Tablets
Priligy is specifically indicated for a defined patient population meeting specific criteria for premature ejaculation diagnosis and treatment.
Primary Indications
- Adult Men Aged 18-64: Specifically licensed for this age group
- Diagnosed Premature Ejaculation: Confirmed by healthcare professional
- Good General Health: No significant cardiac or hepatic conditions
- Lifelong or Acquired PE: Suitable for both types of premature ejaculation
- Regular Sexual Activity: Designed for men with anticipated sexual activity
Ideal Candidate Profile
- Motivated for Treatment: Committed to following usage guidelines
- Stable Partner Relationship: Although not essential, may enhance outcomes
- Good Compliance: Willing to adhere to dosing instructions
- Realistic Expectations: Understands medication benefits and limitations
- Regular Medical Follow-up: Committed to required healthcare reviews
Diagnostic Criteria for Appropriate Use
Clinical Diagnosis Required
Premature ejaculation must be formally diagnosed by a healthcare professional based on:
- Ejaculation within approximately one minute of vaginal penetration (lifelong PE)
- Inability to delay ejaculation during all or nearly all sexual encounters
- Negative personal consequences such as distress or relationship avoidance
Treatment Goals
Appropriate candidates should have clear treatment objectives including:
- Increasing intravaginal ejaculatory latency time
- Improving control over ejaculation
- Reducing personal distress and interpersonal difficulty
- Enhancing sexual satisfaction for both partners
Who Should Not Use Priligy: Contraindications
Several medical conditions and patient characteristics absolutely prohibit the use of Priligy due to potentially serious health risks.
Absolute Contraindications
- Cardiac Conditions: Heart failure, conduction abnormalities, significant heart disease
- History of Syncope: Recurrent fainting or blackouts
- Mania or Severe Depression: Current or historical bipolar or major depressive disorder
- Moderate/Severe Liver Impairment: Child-Pugh Class B or C
- Age Restrictions: Under 18 or over 64 years old
Medication Contraindications
- MAO Inhibitors: Concurrent or recent use (within 14 days)
- Other Antidepressants: SSRIs, SNRIs, tricyclics
- Strong CYP3A4 Inhibitors: Ketoconazole, itraconazole, ritonavir
- Antipsychotics: Particularly thioridazine
- Recreational Drugs: Ecstasy, LSD, poppers
Specific Population Exclusions
| Population Group | Exclusion Reason | Risk Level |
|---|---|---|
| Adolescents (<18 years) | Safety and efficacy not established | High |
| Elderly (>64 years) | Increased cardiovascular risk | High |
| Women | Not indicated for female use | Not applicable |
| Severe renal impairment | Limited safety data | Moderate-High |
| Uncontrolled hypertension | Cardiovascular risk | High |
To Be Taken With Food: Meal Timing & Effects
Priligy can be taken with or without food, but understanding how food affects absorption and side effects can optimise your treatment experience.
Taking With Food: Benefits
Advantages of Food Co-administration
- Reduced Nausea: Food in stomach may decrease gastrointestinal upset
- Slower Absorption: May moderate peak concentration, potentially reducing side effects
- Better Tolerance: Some users report fewer dizziness symptoms with food
- Convenience: Can be taken with regular meals for ease of remembering
Optimal Food Choices
Recommended Meal Types
- Light Meals: Sandwiches, salads, soups
- Low-Fat Options: Avoid heavy, greasy foods that may cause discomfort
- Balanced Nutrition: Include protein and complex carbohydrates
- Adequate Hydration: Maintain water intake with meals
Food Interaction Research Findings
Absorption Timing
When taken with a high-fat meal, peak plasma concentrations (Tmax) may be delayed by approximately 30 minutes, but overall absorption (AUC) remains largely unchanged.
Clinical Significance
The modest delay in absorption with food is not considered clinically significant for most users, allowing flexibility in administration relative to meals.
Individual Variation
Some individuals may experience noticeably different side effect profiles when taking with food versus on an empty stomach.
Taking Priligy Without Food: Considerations
While Priligy can be taken on an empty stomach, understanding the implications of this administration method helps manage expectations and potential side effects.
Faster Absorption Profile
Pharmacokinetic Effects
- Rapid Onset: Peak concentrations reached slightly faster
- Higher Cmax: Potentially higher maximum concentration
- Predictable Timing: More consistent absorption between doses
- Quickest Effect: May provide most rapid therapeutic action
Potential Challenges
Side Effect Considerations
- Increased Nausea: Higher incidence of gastrointestinal upset
- Enhanced Dizziness: Potentially more pronounced orthostatic effects
- Tolerance Issues: Some users find empty stomach administration less comfortable
- Timing Precision: Requires more careful planning around meals
Optimal Empty Stomach Administration
Timing Strategy
- Take 1-2 hours after last meal
- Allow 30-60 minutes before next meal
- Maintain consistent timing between doses
- Plan around anticipated sexual activity
Side Effect Management
- Have simple carbohydrates available if needed
- Remain seated for 30 minutes after administration
- Keep water readily available
- Monitor for dizziness when standing
Hydration Emphasis
- Drink full glass of water with tablet
- Continue hydration throughout effect period
- Avoid dehydration before administration
- Monitor urine colour as hydration indicator
Special Conditions & Precautions
Certain medical conditions and circumstances require special consideration and monitoring when using Priligy to ensure safe administration.
Cardiovascular Conditions
Precautions Required
- Orthostatic Hypotension: Increased risk of blood pressure drops
- Heart Rate Effects: May cause tachycardia or bradycardia
- Syncope Risk: Higher incidence of fainting episodes
- Monitoring Needed: Regular cardiovascular assessment
Psychiatric Conditions
Mood and Mental Health
- Mood Changes: May induce anxiety, agitation, or mood swings
- Mania Risk: Contraindicated in bipolar disorder
- Suicidal Ideation: Rare reports of suicidal thoughts
- Withdrawal Effects: Dizziness, anxiety upon discontinuation
Hepatic and Renal Impairment
Metabolic Considerations
- Liver Function: Contraindicated in moderate-severe impairment
- Renal Function: Use with caution in severe renal impairment
- Metabolic Clearance: Reduced in hepatic impairment
- Dose Adjustment: May be necessary in mild impairment
Pregnancy and Breast-Feeding Considerations
Important Information for Female Partners
While Priligy is not used by women, important considerations apply regarding pregnancy and breast-feeding for female partners of men using this medication:
- Contraception Advice: Priligy does not replace need for contraception
- Pregnancy Planning: No known direct effects on sperm or fertility
- Partner Health: Female partners should consult their doctor if pregnant or breast-feeding
- Medication Transfer: No risk of medication transfer through semen
Additional Special Populations
| Population | Special Considerations | Monitoring Requirements |
|---|---|---|
| Epilepsy Patients | Possible lowered seizure threshold | Increased seizure monitoring |
| Bleeding Disorders | Potential increased bleeding risk | Monitor for unusual bruising or bleeding |
| Glaucoma Patients | Possible intraocular pressure changes | Regular ophthalmological review |
| Elderly (approaching 64) | Increased sensitivity to side effects | Close cardiovascular monitoring |
Frequently Asked Questions
Can I take Priligy every day like regular antidepressants?
No, Priligy should not be taken daily like traditional antidepressants. It is specifically designed for on-demand use, with a maximum frequency of once every 24 hours. The medication has a different pharmacokinetic profile than daily SSRIs, with rapid absorption and elimination making it suitable for occasional use rather than continuous dosing. Taking Priligy daily would increase the risk of side effects without providing additional benefits for premature ejaculation. Traditional SSRIs used off-label for PE require daily dosing and take weeks to become effective, whereas Priligy works from the first dose when taken 1-3 hours before sexual activity.
What should I do if I miss the optimal 1-3 hour timing window?
If you miss the optimal 1-3 hour timing window, do not take Priligy less than one hour before sexual activity as it may not have sufficient time to become effective. Similarly, taking it more than 3 hours in advance may mean the peak effects have diminished by the time of sexual activity. In this situation, it's better to skip the dose for that occasion rather than taking it at suboptimal timing. Remember that Priligy can only be taken once every 24 hours, so if you miss the timing window, wait until the next appropriate occasion to use it. Planning and anticipation are key components of successful Priligy use.
Can I drink alcohol if I take Priligy earlier in the day?
No, you should avoid alcohol completely on days you take Priligy, regardless of how much time has passed since taking the medication. Alcohol can increase the risk and severity of Priligy's side effects, particularly dizziness, drowsiness, and the risk of fainting. The combination may also impair judgment and increase the risk of accidental injury. Since Priligy has effects that last for several hours and alcohol can remain in your system, it's safest to avoid alcohol entirely on days you use this medication. This precaution helps ensure your safety and reduces the risk of potentially dangerous side effects.
How long should I continue Priligy treatment before assessing its effectiveness?
You should assess the effectiveness of Priligy after approximately 4 weeks of use or after 6 doses, whichever comes first. This assessment should ideally be done with your healthcare provider to determine if continuing treatment is appropriate. The MHRA requires this formal evaluation to ensure the medication is providing benefit without unacceptable side effects. During this assessment, you and your doctor will review the improvement in ejaculatory control, any side effects experienced, and whether the current dosage (30mg or 60mg) is optimal. If treatment continues, further reviews should occur at least every six months to ensure ongoing appropriateness.
What should I do if I experience dizziness after taking Priligy?
If you experience dizziness after taking Priligy, immediately sit or lie down to prevent falls and injury. Remain in this position until the dizziness passes. Make sure you have taken the medication with a full glass of water as dehydration can worsen this side effect. Avoid standing up quickly from sitting or lying positions. Do not drive, operate machinery, or engage in any potentially dangerous activities while experiencing dizziness. If fainting occurs or if dizziness is severe or persistent, contact your healthcare provider promptly. They may recommend adjusting your dose or considering alternative treatments. This side effect is more common when starting treatment and may improve with continued use.
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Medical Content Manager
Nabeel is a co-founder and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
Medical Doctor
Dr. Feroz is a GMC-registered doctor and a medical reviewer at Chemist Doctor. He oversees acute condition and urgent care guidance.
Medical Director
Usman is a co-founder and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 20 November 2025
Next Review: 20 May 2026
Published on: 20 November 2025
Last Updated: 21 November 2025
