How To Use Azithromycin
Step-by-step guide for taking azithromycin tablets in the UK, including dosing schedules, food interactions, and missed dose instructions.
Key Takeaways
- Standard course: 500mg once daily for 3 days (or 5-day regimen)
- Chlamydia treatment: Single 1000mg dose
- Timing: Take 1 hour before or 2 hours after food
- Missed dose: Take when remembered unless near next dose
- Completion: Finish full course even if symptoms improve
Azithromycin is a widely prescribed antibiotic effective against various bacterial infections. Proper administration ensures optimal effectiveness and minimizes side effects.
Azithromycin Dosage Instructions
For Adults & Children ≥45kg
3-day course: 500mg (1-2 tablets) once daily for 3 consecutive days
5-day course: 500mg on Day 1, then 250mg daily on Days 2-5
For Specific Infections
Chlamydia: Single 1000mg dose (2x500mg tablets)
Gonorrhoea: 1000-2000mg with ceftriaxone (as prescribed)
How To Take Azithromycin Tablets
Step 1: Check Timing
Take 1 hour before or 2 hours after food for optimal absorption.
Step 2: Prepare Dose
Swallow whole with water. 500mg tablets can be split along the score line if needed.
Step 3: Maintain Schedule
Take at the same time daily (e.g., always with breakfast).
Tip: If stomach upset occurs, take with a small amount of food (though this may slightly reduce absorption).
Azithromycin Treatment Timeline
| Time After Dose | Biological Effect | Expected Symptom Improvement |
|---|---|---|
| 24 hours | Peak tissue concentration | Reduced fever/pain in responsive infections |
| 3 days | Sustained therapeutic levels | Significant symptom relief for most infections |
| 5-7 days post-treatment | Active metabolites still present | Complete resolution for simple infections |
Note: Continue taking azithromycin for 48 hours after symptoms resolve to prevent recurrence.
What To Do If You Miss a Dose
If <12 hours late:
Take the missed dose immediately, then continue normal schedule.
If >12 hours late:
Skip the missed dose and take next dose at usual time.
Storage Advice
- Keep in original packaging at room temperature (15-25°C)
- Store in a dry place away from direct sunlight
- Keep out of sight and reach of children
- Do not use after expiry date on blister pack
Need Antibiotic Treatment?
If you're experiencing symptoms of a bacterial infection, our UK-registered doctors can help determine if Azithromycin Tablets is appropriate for your condition through a confidential online consultation.
Secure Prescription & Next-Day Delivery
MHRA-compliant | GPhC-registered pharmacy | Discreet packaging
Start UTI ConsultationFrequently Asked Questions
Can I crush azithromycin tablets?
Not recommended. The film coating ensures proper absorption. Children <45kg should use the oral suspension instead.
Why must I avoid antacids with azithromycin?
Antacids containing aluminium/magnesium can reduce absorption by up to 50%. Separate doses by 2 hours if needed.
What if I vomit after taking a dose?
If vomiting occurs within 1 hour of taking, consider it a missed dose. After 1 hour, no retake is needed as absorption is likely complete.
Can I take azithromycin at night?
Yes, but take 2 hours after dinner. Nighttime dosing may help if you experience nausea during the day.
How long does azithromycin stay in your system?
Azithromycin has a 68-hour half-life, meaning therapeutic levels persist for 5-7 days after the last dose.
Need Antibiotic Treatment?
If you're experiencing symptoms of a bacterial infection, our UK-registered doctors can help determine if Azithromycin Tablets is appropriate for your condition through a confidential online consultation.
Secure Prescription & Next-Day Delivery
MHRA-compliant | GPhC-registered pharmacy | Discreet packaging
Start UTI ConsultationRelated Guides
Medical Content Manager
Nabeel is a co-founder and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
Medical Doctor
Dr. Feroz is a GMC-registered doctor and a medical reviewer at Chemist Doctor. He oversees acute condition and urgent care guidance.
Medical Director
Usman is a co-founder and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 03 November 2025
Next Review: 05 May 2026
Published on: 03 November 2025
Last Updated: 04 November 2025
