Nevolat Injections

What is Nevolat?

Nevolat is a prescription weight-loss medication containing the active substance liraglutide, presented as a 6 mg/ml solution for injection in a pre-filled pen. It belongs to a class of medicines called GLP-1 receptor agonists, designed to mimic the effects of the naturally occurring hormone glucagon-like peptide-1 (GLP-1) that regulates appetite.

Mechanism of Action

When administered, Nevolat works through a dual-action mechanism:

• Appetite regulation: Acts on receptors in the hypothalamus (brain's appetite center) to increase satiety signals
• Gastric emptying: Slows down food movement from stomach to intestine, prolonging fullness
• Glucose regulation: Enhances insulin secretion while suppressing glucagon release. For detailed mechanism studies, refer to scientific research.

Imagine your appetite control system as a complex thermostat - Nevolat helps recalibrate this system to reduce hunger signals and increase satisfaction after smaller meals.

What is Nevolat Used For?

Nevolat is indicated for weight management as an adjunct to:

• Reduced-calorie diet
• Increased physical activity

Approved Patient Groups

Nevolat Dietary & Exercise Requirements

Nevolat is not a standalone solution - it requires concurrent lifestyle modifications:

Essential Components

Hydration Guidance

Due to gastrointestinal side effects, maintain:

• 2-3 litres water daily
• Electrolyte balance during initial treatment phase

Before Using Nevolat

Essential considerations before initiating treatment:

Medical History Assessment

• Thyroid disease history (especially medullary thyroid carcinoma)
• Pancreatitis history (acute or chronic)
• Gallbladder disease
• Renal impairment (eGFR assessment)
• Depression or suicidal ideation

Required Baseline Tests

1. Thyroid function tests (TSH, calcitonin)
2. Pancreatic enzymes (amylase, lipase)
3. Renal function (eGFR, creatinine)
4. Liver function (ALT, AST)

Nevolat Contraindications

Absolute contraindications where Nevolat must not be used:

Absolute Contraindications

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Hypersensitivity to liraglutide or excipients
• Severe gastrointestinal disease (gastroparesis, IBD)

Special Warnings

Special Population Considerations

Elderly Patients (≥75 years)

• Limited clinical experience
• Not recommended due to increased dehydration risk

Renal Impairment

• Mild-moderate impairment: No dose adjustment
• Severe impairment (eGFR <30): Avoid use
• End-stage renal disease: Contraindicated

Hepatic Impairment

• Mild-moderate (Child-Pugh A-B): Caution advised
• Severe (Child-Pugh C): Not studied - avoid use

Nevolat and Other Medicines

Significant interactions requiring monitoring:

High-Risk Combinations

• Insulin/Sulfonylureas: Increased hypoglycaemia risk (dose reduction needed)
• Oral anticoagulants (warfarin): Requires frequent INR monitoring

Absorption Interactions

Due to delayed gastric emptying:

• Take oral medications 1 hour before Nevolat injection
• Particularly critical for:
  • Antibiotics
  • Oral contraceptives
  • Thyroid medications

Pregnancy & Breastfeeding

Pregnancy

• Contraindicated during pregnancy
• Discontinue immediately if pregnancy occurs
• Use effective contraception during treatment

Breastfeeding

• Avoid during breastfeeding
• Unknown if liraglutide excreted in human milk
• Potential risk to infant based on animal studies

Driving & Machine Operation

• No direct impairment of driving ability
• Caution advised due to possible:
  • Dizziness (especially first 3 months)
  • Hypoglycaemia (when combined with other agents)
• Do not drive if experiencing warning signs of low blood sugar

Nevolat Ingredients

Active Substance

• Liraglutide 6 mg/ml

Excipients

Sodium Content

• Less than 1 mmol sodium (23 mg) per dose
• Essentially 'sodium-free'

How to Use Nevolat

Preparation Steps

1. Check pen label (ensure correct medication)
2. Inspect solution: must be clear and colourless
3. Attach new needle (32G recommended)
4. Perform flow check before first use

Injection Technique

• Sites: Abdomen, thighs, or upper arms
• Angle: 90° insertion (45° if lean)
• Depth: Subcutaneous tissue only
• Rotation: Change site daily

Post-Injection Protocol

1. Hold dose button until counter shows "0"
2. Count slowly to 6 before needle removal
3. Dispose needle immediately
4. Replace pen cap

Nevolat Dosage Guidelines

Standard Titration Schedule

Dose Adjustment Criteria

• If significant GI side effects: maintain current dose for 1 week before increasing
• Maximum dose: 3.0 mg daily
• Never exceed recommended dose

Administration Instructions

Step-by-step injection guide:

Dose Selection

1. Turn dose selector until correct dose aligns with pointer
2. Verify dose counter shows exact mg (0.6, 1.2, 1.8, 2.4 or 3.0)
3. Never use pen clicks to determine dose

Injection Process

1. Insert needle at 90° angle
2. Press and hold dose button until counter shows "0"
3. Keep needle inserted for 6 seconds after injection
4. Withdraw needle gently

Post-Injection Care

• Apply light pressure if bleeding occurs
• Do not rub injection site
• Rotate sites daily to prevent lipodystrophy

Missed Dose Management

General Principles

• Do NOT double doses
• Do NOT increase next dose

Time-Based Guidance

Overdose Information

Symptoms

• Severe nausea/vomiting
• Hypoglycaemia (if combined with other agents)
• Dehydration

Management

1. Seek immediate medical attention
2. Bring medication packaging
3. Symptomatic treatment:
   • IV fluids for dehydration
   • Glucose for hypoglycaemia
   • Antiemetics if severe vomiting

Nevolat Side Effects

Understanding potential adverse reactions is crucial. For comprehensive safety profiles, consult authoritative resources.

Very Common (more than 1 in 10 people)

• Nausea (39.3%)
• Diarrhoea (20.9%)
• Headache (13.6%)

Common (1 in 10 to 1 in 100 people)

• Vomiting
• Fatigue
• Injection site reactions
• Gallstones

Serious Side Effects

How to Store Nevolat

Unopened Pens

• Refrigerate at 2-8°C
• Do not freeze
• Keep in original carton

In-Use Pens

• May store at ≤30°C
• Use within 30 days
• Keep pen cap on when not in use

Disposal

• Dispose needles in sharps container
• Return unused pens to pharmacy
• Never dispose in household waste

Pack Information

Pack Sizes

• 1 pre-filled pen
• 3 pre-filled pens
• 5 pre-filled pens

Components

• Pre-filled pen (3ml solution)
• Needles NOT included
• Instructions for use

Appearance

• Clear, colourless solution
• Pre-filled disposable pen

Where Can I Buy Nevolat Online in the UK