Mounjaro Injections

What is Mounjaro?

Mounjaro is a prescription medication containing the active substance tirzepatide, presented as a solution for injection in a pre-filled KwikPen®. It belongs to a class of medicines called dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists.

Mechanism of Action

Mounjaro works through a dual-action mechanism:

• Appetite regulation: Acts on receptors in the brain to increase satiety signals and reduce hunger
• Metabolic enhancement: Improves insulin sensitivity and reduces glucagon secretion
• Gastric emptying: Slows down food movement from stomach to intestine

Imagine your appetite control system as a complex thermostat - Mounjaro helps recalibrate this system to reduce hunger signals and increase satisfaction after smaller meals.

What is Mounjaro Used For?

Mounjaro is indicated for weight management as an adjunct to:

• Reduced-calorie diet
• Increased physical activity

Approved Patient Groups

Before Using Mounjaro

Essential considerations before initiating treatment:

Medical History Assessment

• Thyroid disease history (especially medullary thyroid carcinoma)
• Pancreatitis history (acute or chronic)
• Gastrointestinal disorders (gastroparesis)
• Diabetic retinopathy or macular oedema
• Renal impairment

Required Baseline Tests

1. Thyroid function tests (TSH, calcitonin)
2. Pancreatic enzymes (amylase, lipase)
3. Renal function (eGFR, creatinine)
4. Liver function (ALT, AST)
5. Cardiovascular assessment

Mounjaro Contraindications

Absolute contraindications where Mounjaro must not be used:

Absolute Contraindications

• Personal or family history of medullary thyroid carcinoma (MTC)
• Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Hypersensitivity to tirzepatide or excipients
• Severe gastrointestinal disease (gastroparesis)

Special Warnings

Special Population Considerations

Elderly Patients (≥75 years)

• Limited clinical experience
• Increased risk of dehydration - monitor fluid intake

Renal Impairment

• Mild-moderate impairment: No dose adjustment
• Severe impairment: Use with caution

Hepatic Impairment

• Limited data available
• Use with caution in severe impairment

Mounjaro and Other Medicines

Significant interactions requiring monitoring:

High-Risk Combinations

• Insulin/Sulfonylureas: Increased hypoglycaemia risk (dose reduction needed)
• Oral contraceptives: Reduced efficacy - use barrier methods

Absorption Interactions

Due to delayed gastric emptying:

• Take oral medications 1 hour before Mounjaro injection
• Particularly critical for:
  • Antibiotics
  • Thyroid medications
  • Blood thinners (warfarin)

Pregnancy & Breastfeeding

Pregnancy

• Contraindicated during pregnancy
• Discontinue immediately if pregnancy occurs
• Use effective contraception during treatment

Breastfeeding

• Unknown if tirzepatide passes into breast milk
• Not recommended during breastfeeding
• Discuss alternatives with your doctor

Driving & Machine Operation

• No direct impairment of driving ability
• Caution advised due to possible:
  • Dizziness
  • Hypoglycaemia (when combined with other agents)
  • Fatigue
• Do not drive if experiencing warning signs of low blood sugar

Mounjaro Ingredients

Active Substance

• Tirzepatide

Excipients

Sodium Content

• Less than 1 mmol sodium (23 mg) per dose
• Essentially 'sodium-free'

How to Use Mounjaro KwikPen

Preparation Steps

1. Wash hands thoroughly
2. Remove pen cap and inspect solution (should be clear and colorless to slightly yellow)
3. Attach new needle
4. Prime the pen to remove air bubbles

Injection Technique

• Sites: Abdomen, thighs, or upper arms
• Angle: 90° insertion
• Rotation: Change injection site weekly
• Duration: Hold dose button for 5 seconds after injection

Post-Injection Protocol

1. Apply light pressure if bleeding occurs
2. Carefully replace outer needle shield
3. Unscrew and dispose of needle in sharps container
4. Replace pen cap

Mounjaro Dosage Guidelines

Standard Titration Schedule

Dose Adjustment Criteria

• Each dose increase requires at least 4 weeks at current dose
• Maximum dose: 15 mg weekly
• Do not increase dose if experiencing significant side effects

Administration Instructions

Step-by-step injection guide:

Dose Selection

1. Turn dose knob until it stops at 0.6ml position
2. Confirm dose indicator shows correct setting
3. Never attempt partial doses

Injection Process

1. Insert needle at 90° angle into clean skin
2. Press and hold dose button completely
3. Count slowly to 5 while keeping needle inserted
4. Withdraw needle gently

Post-Injection Care

• Check dose window for confirmation of complete delivery
• Do not rub injection site
• Rotate sites weekly to prevent lipodystrophy

Missed Dose Management

General Principles

• Do NOT double doses
• Minimum 3 days between doses

Time-Based Guidance

Overdose Information

Symptoms

• Severe nausea/vomiting
• Hypoglycaemia
• Dehydration
• Abdominal pain

Management

1. Seek immediate medical attention
2. Bring medication packaging
3. Symptomatic treatment:
   • IV fluids for dehydration
   • Glucose for hypoglycaemia
   • Antiemetics if severe vomiting

Possible Side Effects

Very Common (more than 1 in 10 people)

• Nausea
• Diarrhoea
• Vomiting
• Abdominal pain
• Constipation

Common (1 in 10 to 1 in 100 people)

• Decreased appetite
• Indigestion (dyspepsia)
• Bloating
• Burping
• Reflux or heartburn
• Hair loss
• Fatigue
• Injection site reactions

Serious Side Effects

How to Store Mounjaro

Unused Pens

• Refrigerate at 2-8°C
• Do not freeze
• Keep in original carton

In-Use Pens

• May store at ≤30°C
• Use within 30 days of first use
• Discard after 4 doses

Disposal

• Dispose needles in sharps container
• Return unused pens to pharmacy
• Never dispose in household waste

Pack Information

Pack Sizes

• 1 pre-filled KwikPen (4 doses)
• 3 pre-filled KwikPens (12 doses)

Components

• Pre-filled pen (4 doses of 0.6ml each)
• Needles NOT included
• Instructions for use

Appearance

• Clear, colorless to slightly yellow solution
• Pre-filled disposable KwikPen

Where Can I Buy Mounjaro Online in the UK