How To Use Lariam Tablets
Follow these instructions carefully for effective malaria prevention or treatment. Learn more about malaria risks.
Key Takeaways
- Prevention: Start 10 days before travel; take weekly
- Treatment: Single dose (may split for side effects)
- Administration: Swallow whole with food/water; avoid lying down
- Duration: Continue 4 weeks post-travel for prevention
- Critical: Monitor for mood changes/dizziness (stop if severe)
Lariam (mefloquine) is an effective antimalarial medication used for both prevention and treatment of malaria. Proper usage is essential for maximum effectiveness and safety.
Malaria Prevention with Lariam
- 10 days before travel: Take first 250mg dose to check tolerance.
- 3 days before travel: Take second dose.
- Weekly during travel: Continue every 7 days (same weekday).
- 4 weeks after return: Complete final doses to cover incubation period.
Dosing Table for Prevention
| Weight/Group | Dose | Frequency |
|---|---|---|
| Adults & Children ≥45kg | 250mg (1 tablet) | Weekly |
| Children 20-30kg | 125mg (½ tablet) | Weekly |
| Children 5-19kg | 62.5mg (¼ tablet) | Weekly |
Note: A full prevention course requires at least 6 doses (2 pre-travel + 4 post-travel).
Malaria Treatment with Lariam
- Initial dose: 15-25mg/kg (max 1,500mg).
- Split dosing: May divide into 2-3 doses 6-8 hours apart to reduce side effects.
- Follow-up: Seek medical care even if symptoms improve.
How to Take Lariam Tablets
- Swallow whole: Do not crush or chew—bitter taste may cause vomiting.
- With food/water: Take after a meal to reduce nausea.
- Upright position: Stay seated/standing for 30 mins after dosing to prevent throat irritation.
- Timing: Evening doses may minimize dizziness.
What to Avoid
- Alcohol: Worsens dizziness and psychiatric side effects.
- Halofantrine/quinine: Risk of fatal heart arrhythmias.
- Typhoid vaccine: Separate by ≥3 days (Lariam reduces vaccine efficacy).
Missed Dose Instructions
| Situation | Action |
|---|---|
| Prevention: ≤48 hours late | Take immediately, then resume weekly schedule |
| Prevention: >48 hours late | Skip missed dose; take next dose on scheduled day |
| Treatment: Missed split dose | Take as soon as possible; do NOT double dose |
If unsure, consult your doctor. Missing multiple prevention doses increases malaria risk.
Safety Precautions
- Suicidal thoughts or severe depression
- Hallucinations or paranoia
- Irregular heartbeat or fainting
- Severe skin reactions (blistering/peeling)
Monitoring During Use
- Mental health: Track mood changes, nightmares, or anxiety.
- Physical symptoms: Report persistent dizziness or balance issues.
- Activities: Avoid driving/piloting if side effects occur.
Frequently Asked Questions
Can I take Lariam on an empty stomach?
No—always take with food to reduce nausea. A fatty meal improves absorption.
Why start Lariam 10 days before travel?
To identify intolerable side effects (e.g., severe anxiety) before entering malaria-risk areas.
How long do side effects last after stopping?
Dizziness/balance issues may persist for months due to Lariam's long half-life (2-4 weeks).
Can I take Lariam for over a year?
No—maximum duration is 12 months due to cumulative neuropsychiatric risks.
What if I vomit after taking a dose?
If vomiting occurs within 30 minutes, take another full dose. After 30 minutes, assume absorption occurred.
Need Treatment for malaria
If you're experiencing symptoms of a bacterial infection, our UK-registered doctors can help determine if Lariam Tablets is appropriate for your condition through a confidential online consultation.
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Medical Content Manager
Nabeel is a co-founder and medical content manager of Chemist Doctor. He works closely with our medical team to ensure the information is accurate and up-to-date.
Medical Doctor
Dr. Feroz is a GMC-registered doctor and a medical reviewer at Chemist Doctor. He oversees acute condition and urgent care guidance.
Medical Director
Usman is a co-founder and medical director of Chemist Doctor. He leads the organisation's strategic vision, bridging clinical and operational priorities.
Review Date: 03 November 2025
Next Review: 05 May 2026
Published on: 03 November 2025
Last Updated: 04 November 2025
