Question 1

How quickly does Sandrena start working?

Accepted Answer

Hot flushes often improve within 2–4 weeks of starting Sandrena, with full benefit by 3 months. Vaginal dryness and sleep disturbances may take longer to resolve, typically 3–6 months.

Question 2

Does Sandrena cause weight gain?

Accepted Answer

Weight gain is not a proven side effect of transdermal estradiol. Any minor fluid retention may occur initially but usually settles. Lifestyle factors are the main contributors to weight changes during menopause.

Question 3

Can I use Sandrena if I have a history of breast cancer?

Accepted Answer

No. Sandrena is contraindicated in women with known or suspected breast cancer or other oestrogen‑dependent malignancies. Discuss alternative non‑hormonal treatments with your oncologist.

Question 4

How do I apply Sandrena gel correctly?

Accepted Answer

Apply the gel once daily to clean, dry skin on the lower abdomen or upper thighs, alternating sites. Do not apply to breasts or broken skin. Allow to dry for a few minutes before dressing.

Question 5

What are the risks of Sandrena compared to oral HRT?

Accepted Answer

Transdermal estradiol carries a lower risk of blood clots (deep vein thrombosis) and does not significantly increase triglycerides or inflammatory markers, making it suitable for women with higher cardiovascular risk.