Tadalafil Tablets

What is Tadalafil?

Tadalafil is a prescription medication containing the active substance tadalafil, presented as film-coated tablets. It belongs to a class of medicines called phosphodiesterase type 5 (PDE5) inhibitors.

Mechanism of Action

Tadalafil works through a targeted mechanism:

• Vasodilation: Enhances blood flow to penile tissues during sexual stimulation
• PDE5 inhibition: Blocks the enzyme that breaks down cyclic guanosine monophosphate (cGMP)
• Erection facilitation: Maintains higher cGMP levels, supporting natural erection processes
• Extended duration: Provides up to 36 hours of effectiveness

Think of Tadalafil as a key that unlocks the natural physiological response to sexual stimulation, allowing for improved blood flow to the penis when you're sexually aroused, with effects lasting much longer than other similar medications.

What is Tadalafil Used For?

Tadalafil is indicated for the treatment of erectile dysfunction in adult men. It can be used in two different ways:

Approved Patient Groups

Usage Options

• As-needed treatment: Taken before anticipated sexual activity
• Once-daily treatment: Taken at the same time each day for continuous effectiveness

Before Using Tadalafil

Essential considerations before initiating treatment:

Medical History Assessment

• Cardiovascular disease history
• Liver or kidney impairment
• Blood cell disorders (sickle cell anemia, leukemia)
• Penile deformities (Peyronie's disease)
• History of vision or hearing problems
• Stomach ulcers or bleeding disorders
• Benign prostatic hyperplasia (BPH)

Required Baseline Tests

1. Cardiovascular assessment
2. Blood pressure measurement
3. Liver and kidney function tests (if indicated)

Tadalafil Contraindications

Absolute contraindications where Tadalafil must not be used:

Absolute Contraindications

• Concomitant use of nitrates (for chest pain)
• Hypersensitivity to tadalafil or excipients
• Severe cardiovascular disease
• Recent stroke or heart attack (within last 6 months)
• Uncontrolled hypertension or hypotension

Special Warnings

Special Population Considerations

Elderly Patients (≥65 years)

• Increased sensitivity to effects
• May require lower starting dose
• Higher likelihood of concomitant medications

Renal Impairment

• Mild impairment (CrCl 51-80 mL/min): Maximum 10mg dose for as-needed use
• Moderate impairment (CrCl 31-50 mL/min): Maximum 10mg dose for as-needed use, 5mg maximum for daily use
• Severe impairment (CrCl ≤30 mL/min): Maximum 5mg dose

Hepatic Impairment

• Mild-moderate impairment (Child-Pugh Class A or B): Maximum 10mg dose
• Severe impairment (Child-Pugh Class C): Not recommended

Tadalafil and Other Medicines

Significant interactions requiring monitoring:

High-Risk Combinations

• Nitrates: Dangerous blood pressure drop - absolute contraindication
• Alpha-blockers: Increased hypotension risk - separate dosing times
• HIV protease inhibitors: Increased tadalafil levels - maximum 10mg in 72 hours
• Riociguat: Dangerous hypotension - contraindicated

Other Interactions

• Antifungal medications (ketoconazole, itraconazole)
• Antibiotics (erythromycin, clarithromycin)
• Blood pressure medications
• Other erectile dysfunction treatments
• Grapefruit juice (may increase side effects)

Pregnancy & Breastfeeding

Pregnancy

• Not indicated for use in women
• No established safety profile during pregnancy

Breastfeeding

• Not indicated for use in women
• Unknown if tadalafil passes into breast milk

Driving & Machine Operation

• Possible dizziness or visual disturbances
• Caution advised when driving or operating machinery
• Do not drive if experiencing vision changes or dizziness
• Effects may be potentiated by alcohol

Tadalafil Ingredients

Active Substance

• Tadalafil

Excipients

Lactose Content

• Contains lactose
• Not suitable for lactose intolerant patients

How to Use Tadalafil

Administration Instructions

1. Take tablet with a glass of water
2. For as-needed use: Approximately 30-60 minutes before sexual activity
3. For daily use: Take at the same time each day
4. Can be taken with or without food
5. Avoid high-fat meals which may delay absorption

Important Notes

• Sexual stimulation is required for effectiveness
• Do not take more than once daily
• Not an aphrodisiac - will not increase libido
• Effects may last up to 36 hours

Tadalafil Dosage Guidelines

Standard Dosing Schedule

Dose Adjustment Criteria

• Increase to 20mg if 10mg is ineffective for as-needed use
• Decrease to 5mg if 10mg causes side effects
• Maximum recommended frequency: once per day
• For daily use, may take up to 5 days to reach steady state

Missed Dose Management

As-Needed Regimen

• No fixed dosing schedule
• Take when needed for sexual activity
• Allow at least 24 hours between doses

Daily Regimen

• If you miss a dose, take it as soon as you remember
• If it's almost time for the next dose, skip the missed dose
• Do not take a double dose to make up for a missed one

Timing Considerations

For as-needed use, take approximately 30-60 minutes before anticipated sexual activity. Effects may last up to 36 hours.

Overdose Information

Symptoms

• Severe headache
• Dizziness
• Fainting
• Prolonged erection
• Vision changes
• Nausea
• Flushing
• Indigestion

Management

1. Seek immediate medical attention
2. Bring medication packaging
3. Supportive treatment:
   • Monitor blood pressure
   • Treat symptoms as they occur
   • For priapism, seek urological consultation

Possible Side Effects

Very Common (more than 1 in 10 people)

• Headache
• Indigestion

Common (1 in 10 to 1 in 100 people)

• Back pain
• Muscle aches
• Nasal congestion
• Flushing
• Pain in limbs
• Dizziness

Uncommon (1 in 100 to 1 in 1000 people)

• Fainting
• Eye pain
• Erection lasting more than 4 hours
• Allergic reactions
• Nausea
• Rash

Rare (1 in 1000 to 1 in 10,000 people)

• Sudden vision loss
• Sudden hearing loss
• Heart attack
• Stroke
• Seizures
• Hypertension

Serious Side Effects

How to Store Tadalafil

Storage Conditions

• Store below 25°C
• Keep in original packaging
• Protect from light and moisture
• Keep out of reach of children

Disposal

• Return unused medication to pharmacy
• Do not dispose in household waste
• Follow local regulations for medication disposal

Tadalafil Pack Information

Pack Sizes

• 4 tablets
• 8 tablets
• 12 tablets
• 16 tablets
• 28 tablets (for daily use)

Appearance

• Yellow, almond-shaped, film-coated tablets
• Marked with "C" on one side and dose strength on other
• Dose strength specific markings

Available Strengths

• 2.5mg tablets (yellow)
• 5mg tablets (yellow)
• 10mg tablets (yellow)
• 20mg tablets (yellow)

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